VOZMOZhNOSTI SOVREMENNOY KhIMIOTERAPII VYSOKODIFFERENTsIROVANNOGO RAKA ShchITOVIDNOY ZhELEZY


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Abstract

High differentiated types of thyroid carcinoma (HDTC) constitute more than 90 % of cases. In 10-15 % of patients, distant metastases can be detected that extremely worse the prognosis. Radioactive iodine therapy remains the basis for this group of patients. This treatment provides good results, but only if the tumor cells have the ability to accumulate the radioactive iodine. For patients with radioiodi-nerefractory HDTC, prognosis remains very unfavorable. Standard cytotoxic chemotherapy is applicable with extremely discouraging results. Over the past years, the development of molecular biology has led to the discovery of the numerous targets in thyroid carcinoma. These targets include protooncogens BRAF and RET, VEGFR and PDGFR, associated with angiogenesis, and sodium-iodide symporter. Tyrosine kinase inhibitors are the most studied drugs in the clinical settings; the results of their evaluation allowed to introduce new targeted drugs in the treatment in this group of patients.

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I. S Romanov

Email: drromanov@mail.ru

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