PERSPEKTIVY PRIMENENIYa S-1 V LEChENII BOL'NYKh RAKOM ZhELUDKA
- Authors: Lud A.N1, Abramov M.E1, Meshcheryakov A.A1
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Affiliations:
- Issue: No 10 (2014)
- Pages: 75-78
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/287063
- ID: 287063
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Abstract
The appearance of S-1 - peroral fluorinated pyrimidine - has allowed to take a new look at the treatment of patients with metastatic stomach cancer. The combination of S-1 with cisplatin has provided improvement in overall survival against the background of absence of clinically significant toxicity. The use of S-1 as monotherapy for adjuvant purposes has led to the significant increase in the three-year disease-free survival of patients with stomach cancer (72.2 vs 60.1 %, P < 0.0001). Great interest to the S-1 was confirmed by numerous ongoing international studies which have evaluated the effectiveness of S-1 not only in combination with other cytotoxic drugs, but also with targeted drugs.
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References
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