Nesteroidnye protivovospalitel'nye sredstva v pediatricheskoy praktike -effektivnost' i bezopasnost' primeneniya kombinirovannykh preparatov
- Authors: Erofeeva S.B1
-
Affiliations:
- Issue: No 11 (2014)
- Pages: 85-87
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/287116
- ID: 287116
Cite item
Open Access
Access granted
Abstract
Ibuprofen and paracetamol are referred to the group of non-steroidal anti-inflammatory drugs (NSAIDs), and have the most effective and safe profile for use in pediatric patients. Although in recent years the number of NSAIDs has significantly increased, and currently this group comprises many drugs differing in chemical structure, characteristics of action and application, paracetamol and ibuprofen are the drugs of choice for treatment of pain and fever, particularly in pediatric practice. The combination of these drugs keeps the safety profile and increases the effectiveness of treatment for fever and pain in children.
Full Text
References
- Drug Safety Update. 2008(2): 4, November.
- WHO Model List of Essential Medicines for Children, 3th list, March 2011.
- Kcacty S., Grosso A. Ibuprofen in management of neonatal Patient Ductus Arteriosus. Intensive Crit. Care Nurs. 2005: 21.
- Paik J.H., Ju J.H., Lee J.Y., et al. Two opposing effects of non steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. J. Biol. Chem. 2000; 275: 28173-79.
- Miranda H.F., Sierralta F., Pinardi G. Neostigmine interactions with non steroidal anti-inflammatory drugs. Br. J. Pharmacol. 2002135(7): 1591-97.
- Chandrasekharan N.V., Hu Dai, Lamar Turepu Roos K., et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc. Natl. Acad. Sci. 2002; 99(21): 13926-31.
- Инструкция по применению лекарственного препарата для медицинского применения Парацетамол (Государственный реестр лекарственных средств http://grls.ros-minzdrav.ru/).
- Геппе Н.А. Эффективность и безопасность ибупрофена при лихорадке у детей. Consilium medicum. 2003; 9; 34-43.
- Welker Y., et al. Multicentre, GP based study of the antipyretic activity and the tolerance of ibuprofen in the treatment of febrile syndromes in adults. Med. Mal. Infect. 1998.
- Gazal G., Mackie I.C. A comparison of paracetamol, ibuprofen or their combination for pain relief following extractions in children under general anaesthesia: a randomized controlled trial A comparison of paracetamol, ibuprofen or their combination for pain relief following extractions in children under general anaesthesia: a randomized controlled trial. Int. J. Paediatr. Dent. 2007; 17(3): 169-77.
- Paul I.M., Sturgis S.A., Yang C., et al. Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children. Clin. Ther. 2010; 32(14): 2433-40.
- Purssell E. Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone. Arch. Dis. Child. 2011; 96(12): 1175-79.
- Баранова Л.Н., Купряшина Н.В., Львова Л.В., Мазуренко Д.В., Морозенко О.А., Муратхузина А.Р. и др. Эффективность и безопасность фиксированной комбинации ибупрофен парацетамол при лихорадочном и болевом синдромах в амбулаторной практике. Фарматека. 2012; 5: 69-76
Supplementary files
