GIPOTIREOZ V STRUKTURE TIREOPATIY DETSKOGO VOZRASTA: PUTI VOZNIKNOVENIYa I TAKTIKA TERAPEVTIChESKOGO VEDENIYa


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Abstract

Thyroid hormones are essential for normal functioning of all organs and systems, from the early stages of embryogenesis and throughout life. They have anabolic effects on protein metabolism, catabolic action on fat metabolism, and indirectly regulates carbohydrate metabolism, provide energy processes, oxygen uptake by cells, affect the water-salt balance, myocardial contractility, heart rate, vascular tone; also, they regulate the growth and development of the child. Thyroid dysfunction can occur at any stage of life. In this review, we would like to highlight the main diseases of the thyroid gland in children, which are accompanied by its dysfunction and require medical intervention, and to discuss the feasibility of hormone replacement therapy in the most controversial situations.

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References

  1. Olney R.S., Grosse S.D., Vogt R.F.Jr. Prevalence of congenital hypothyroidism-current trends and future directions: Workshop Summary. Pediatrics. 2010;125;S31.
  2. Szinnai G. Genetics of normal and abnormal thyroid development in humans. Best Pract. Res. Clin. Endocrinol. Metab. 2014;28:133-50.
  3. Polak M., Szinnai G. Thyroid disorders. In: Emery and Rimoin's Principles and Practice of Medical Genetics. Rimoin D.L., Pyeritz R.E., Korf B. (eds.). Philadelphia, 2013. Р. 1-24.
  4. Rastogi M.N., LaFrancchi S.H. Congenital hypothyroidism. Orphanet. J. Rare Dis. 2010;5:17.
  5. Van Vliet G., Deladoey J. Hypothyroidism in infants and children: congenital hypothyroidism; In: Werner and Ingbar's the Thyroid: A Fundamental and Clinical Text. Braverman L.E., Cooper D. (eds). Philadelphia, 2012;790-802.
  6. Muzza M., Rabbiosi S., Vigone M.C., et al. The Clinical and Molecular Characterization of Patients With Dyshormonogenic Congenital Hypothyroidism Reveals Specific Diagnostic Clues for DUOX2 Defects J. Clin. Endocrinol Metab. 2014;99(3):544-53.
  7. Bakker B., Bikker H., Vulsma T., et al. Two decades of screening for congenital hypothyroidism in the Netherlands: TPO gene mutations in total iodide organification defects (an up-date). J. Clin. Endocrinol. Meta. 2000;85:3708-12.
  8. Hishinuma A., Fukata S., Nishiyama S., et al. Haplotype analysis reveals founder effects of thyroglobulin gene mutations C1058R and C1977S in Japan. J. Clin. Endocrinol. Metab. 2006;91:3100-04.
  9. Hye Young Jin, Beom-Hee Lee, Sun-Hee Heo, et al. High Frequency of DUOX2 Mutations in Transient or Permanent Congenital Eutopic Thyroid Glands Horm. Res. Paediatr. 2014;82:252-60. doi: 10.1159/000362235.
  10. Narumi S., Muroya K., Asakura Y., et al. Molecular basis of thyroid dyshormonogenesis: genetic screening in population-based Japanese patients. J. Clin. Endocrinol. Metab. 2011;96:1838-42.
  11. Дедов И.И., Петеркова В.А. Федеральные клинические рекомендации (протоколы) по ведению детей с эндокринными заболеваниями. М., 2014;200-11.
  12. Doeker B.M., Pfaffle R.W., Pohlenz J., et al. Congenital central hypothyroidism due to a homozygous mutation in the thyrotropin beta-subunit gene follows an autosomal recessive inheritance. J. Clin. Endocr. Metab. 1998;83:1762-65.
  13. Gaspar E., Hardenbicker C., Bodo E., et al. Thyrotropin-releasing hormone (TRH): a new player in human hair-growth control. FASEB J. 2010;24:393-403.
  14. Bonomi M., Busnelli M., Beck-Peccoz P., et al. A family with complete resistance to thyrotropin-releasing hormone. New Eng. J. Med. 2009;360:731-34.
  15. Дедов И.И., Мельниченко Г.А., Трошина Е.А. и др. Дефицит йода - угроза развитию и здоровью детей России (Национальный доклад). М., 2006.
  16. Касаткина Э.П., Шилин Д.Е., Пыков М.И. и др. Комплексная ультразвуковая оценка эндемического зоба у детей мегаполиса с легкой йодной недостаточностью. Ультразвуковая диагностика. 1997;4:20.
  17. Einenkel D., Bauch K.H., Benker G. Treatment of juvenile goiter with levothyroxine, iodide or a combination of both: the value of ultrasound grey_scale analysis. Acta Endocrinol. 1992;127:301-6.
  18. Hintze G., Koebberling J. Treatment of iodine deficiency goiter with iodine, levothyroxine or a combination of both. Thyroidol. 1992;4:37-40.
  19. Schumm P.M., Draeger P.M. Drug therapy of goiter. Iodine, thyroid hor mones or combined therapy. Inn. Med. 1993;48:592-98.
  20. Аранович В.В. Катамнез детей с эндемическим зобом. Клиническая и экспериментальная тиреоидология. 2005;1(1).
  21. Консенсус «Эндемический зоб у детей: терминология, диагностика, профилактика и лечение». Проблемы эндокринологии. 1999;6:29-30.
  22. Brix T.H., Hegedus L. Genetic and environmental factors in the aetiology of simple goiter. Ann. Med. 2000;32:153-56.
  23. Matsuda A., Kosugi S.A homozygous missense mutation of the sodium/iodide symporter gene causing iodide transport defect. J. Clin. Endocr. Metab. 1997;82:3966-71.
  24. Volpe R. Autoimmune thyroiditis. Thyroid function and disease. Burrow G.N., Oppenheimer J.H., Volpe R. (eds.). Philadelphia. 1989; 191-207.
  25. Кияев А.В., Савельев Л.И., Герасимова Л.Ю. и др. Распространенность заболеваний щитовидной железы у детей и подростков в йододефицитном регионе. Клин. и экспер. тиреоидол. 2007;3(2):33-8.
  26. Demirbilek H., Kandemir N., Gonc E.N., et al. Hashimoto's thyroiditis in children and adolescents: a retrospective study on clinical, epidemiological and laboratory properties of the disease. J. Pediatr. Endocrinol. Metab. 2007;20: 1199-205.
  27. Касаткина Э.П., Мартынова М.И., Петеркова В.А.КлиническиерекомендацииРоссийской ассоциации эндокринологов по диагностике и лечению аутоиммунного тиреоидита у детей. Клиническая тиреоидология. 2003;1:26.
  28. Самсонова Л.Н., Касаткина Э.П. Нормативы уровня тиреотропного гормона в крови: современное состояние проблемы. Проблемы эндокринологии. 2007;53(6):40-3.
  29. Gopalakrishnan S., Chugh P.K., Chhillar M., et al. Goitrous autoimmune thyroiditis in a pediatric population: a longitudinal study. Pediatrics. 2008;122(3)6:670-74.
  30. Vanderpump M.P.J., Tunbridge W.M.G., French J.M., et al. The incidence of thyroid disorders in the community: a twenty year follow up of the Whickham Survey. Clin. Endocrionol. 1995;43:55-69.
  31. Schumm P.M., Draeger P.M. Drug therapy of goiter. Iodine, thyroid hor mones or combined therapy. Inn. Med. 1993;48:592-98.
  32. Krohn K., Wohlgemuth S., Gerber H., et al. Hot microscopic areas of iodine deficient euthyroid goitres contain constitutively activating TSH receptor mutations. J. Pathol. 2000; 192:37-42.

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