OSOBENNOSTI FARMAKOLOGII VODORASTVORIMOY FORMY VITAMINA D NA OSNOVE MITsELL


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Abstract

Water-soluble (micellized) form of vitamin D is very effective for the correction of D hypovitaminosis, especially in patients with fat malabsorption (hypofunction of the liver and gallbladder, cystic fibrosis, etc.). The present article shows that the micelle formation (ie, the formation of nano-dispersed emulsion) plays a key role in the uptake of vitamin D from foods and pharmaceuticals.

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References

  1. Громова О.А., Торшин И.Ю., Пронин А.В., Рудаков К.В. Систематический анализ неврологических ролей и перспектив использования витамина D для профилактики и лечения цереброваскулярных и демиелинизирующих заболеваний. Журн. невропатологии и психиатрии им. С.С. Корсакова. 2014;12. В печати.
  2. Hollander D., Truscott TC. Mechanism and site of small intestinal uptake of vitamin D3 in pharmacological concentrations. Am. J. Clin. Nutr. 1976;29(9):970-75.
  3. Weber F. Absorption of fat-soluble vitamins. Int. J. Vitam. Nutr. Res. 1983;25:55-65.
  4. Weber F. Absorption mechanisms for fat-soluble vitamins and the effect of other food constituents. Prog. Clin. Biol. Res. 1981;77:119-35.
  5. Lenormand Y., Rautureau M., Mary J.Y., Rambaud J.C. Intestinal absorption of vitamin D, linoleic acid and cholesterol from micellar solutions: study in normal humans by the in situ perfusion method. Biol. Gastroenterol. 1975;8(3):207-21.
  6. Carre M., Miravet L., Hioco D. Solubilization of vitamin D3 in a micellar solution. C. R Seances Soc. Biol. Fil. 1972;166(6):807-11.
  7. MacNaught A.D., Wilkinson A.R. (ed.). Compendium of Chemical Terminology: IUPAC Recommendations (2nd ed.). Oxford: Blackwell Science.
  8. Terminology of polymers and polymerization processes in dispersed systems (IUPAC Recommendations 2011). Pure and Applied Chemistryy. 2011;83(12):2229-59.
  9. Ziani K., Fang Y., McClements D.J. Encapsulation of functional lipophilic components in surfactant-based colloidal delivery systems: vitamin E, vitamin D, and lemon oil. Food Chem. 2012;134(2):1106-12.
  10. McDonald G.B., Lau K.H.,Schy A.L., Wergeda J.E., Baylink D.J. Intestinal metabolism and portal venous transport of 1,25(OH)2D3, 25(OH) D3, and vitamin D3 in the rat. Am. J. Physiol. 1985;248(6):G633-G638.
  11. Sitrin M.D., Pollack K.L., Bolt M.J. Intestinal absorption of 1,25-dihydroxyvitamin D3 in the rat. Am. J. Physiol. 1985;248(6):718-25.
  12. Thompson G.R., Ockner R.K., Isselbacher K.J. Effect of mixed micellar lipid on the absorption of cholesterol and vitamin D3 into lymph. J. Clin. Invest. 1969;48(1):87-95.
  13. Goncalves A., Gleize B. Fatty acids affect micellar properties and modulate vitamin D uptake and basolateral efflux in Caco-2 cells. J. Nutr. Biochem. 2013;24(10):1751-57.
  14. Rautureau M., Rambaud J.C. Aqueous solubilisation of vitamin D3 in normal man. Gut. 1981;22(5):393-7.
  15. Argao E.A., Heubi J.E., Hollis B.W., Tsang R.C. d-Alpha-tocopheryl polyethylene glycol-1000 succinate enhances the absorption of vitamin D in chronic cholestatic liver disease of infancy and childhood. Pediatr. Res. 1992;31(2):146-50.
  16. Li W., Peng H., Ning F., Yao L., Luo M., Zhao Q., Zhu X., Xiong H. Amphiphilic chitosan derivative-based core-shell micelles: synthesis, characterisation and properties for sustained release of Vitamin D3. Food Chem. 2014;152: 307-15.
  17. Pokrovskii N. A mathematical model of the system controlling mediator release from presynaptic endings. Biofizika. 1989;34(3):400-04.
  18. Nik A.M., Corredig M., Wright A.J. Release of lipophilic molecules during in vitro digestion of soy protein-stabilized emulsions. Mol. Nutr. Food Res. 2011;55(Suppl. 2):278-89.
  19. Koynova R., Tihova M. Nanosized self-emulsifying lipid vesicles of diacylglycerol-PEG lipid conjugates: biophysical characterization and inclusion of lipophilic dietary supplements. Biochim. Biophys. Acta. 2010;1798(3):646-53.
  20. Goncalves A., Gleize B., Bott R., Nowicki M., Amiot M.J., Lairon D., Borel P., Reboul E. Phytosterols can impair vitamin D intestinal absorption in vitro and in mice. Mol. Nutr. Food Res. 2011;55(Suppl. 2):303-11.
  21. Thompson W.G., Thompson G.R. Effect of cholestyramine on the absorption of vitamin D3 and calcium. Gut. 1969;10(9):717-22.
  22. http://www.pharma- ingredients.basf.com/ Sta tements/Technical%2520Informations /EN/Pharma%2520Solutions/ EMP%252003071 1 e_Cremophor% 2520EL.pdf
  23. Roy A., Haldar S., Mondal S., Ghosh T.K. Effects of supplemental exogenous emulsifier on performance, nutrient metabolism, and serum lipid profile in broiler chickens. Vet. Med. Int. 2010;2010:262604.
  24. Grove M., Mullertz A., Pedersen G.P., Nielsen J.L. Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state. Eur. J. Pharm. Sci. 2007; 31(1):8-15.
  25. Grove M., Mullertz A., Nielsen J.L, Pedersen G.P. Bioavailability of seocalcitol II: development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides. Eur. J. Pharm. Sci. 2006;28(3): 233-42.

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