Kletochno-molekulyarnye mekhanizmy formirovaniya vospalitel'nogo komponenta v dykhatel'nykh putyakh pri komorbidnykh sostoyaniyakh: gastroezofageal'noy reflyuksnoy bolezni i bronkhial'noy astme


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Abstract

Diseases accompanied by inflammatory changes in the broncho-pulmonary system often have a different etiology, but the formation of the inflammation is caused by a common pathogenetic component - an imbalance of cellular and humoral Th1- Th2-mediated immunity response with undoubted integration of macrophages in the process. Understanding of the features of the phenotyping of macrophages in bronchial asthma, gastroesophageal reflux disease and their combination on the M1 and M2 phenotype and the role of surfactant protein D in this process can facilitate the individualization of therapy. The data on the cellular and molecular mechanisms of formation of inflammation in the broncho-pulmonary system in comorbid states will allow to identify the one of the promising new approaches to pathogenetic therapy of diseases at the early stages of the inflammatory response and correct the balance of M1/M2 macrophage phenotypes through their microenvironment factors.

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