Terapevticheskie vozmozhnosti levonorgestrel-vydelyayushchey vnutrimatochnoy sistemy u zhenshchin v perimenopauze


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Endocrine physiological changes in menopausal women ultimately determine the presence of ovulatory or anovulatory menstrual cycles, which are characterized by abnormally high level of estradiol or abnormal rhythm of its secretion, as well as deficiency of progesterone. Against this background, heavy and/or prolonged menstruation and dysmenorrhea. The results of studies with various levels of evidence (A-C) show that levonorgestrel-releasing intrauterine system (LNG-IUS) Mirena has therapeutic benefits when it is used in women during perimenopause. These benefits are attributable to the combination of high contraceptive reliability with a healing effect for menorrhagia and dysmenorrhea and because of the presence of registered indications for the use of drug as a gestagenic component for the hormone therapy of menopause.

Full Text

Restricted Access

References

  1. Hale G.E., Robertson D.M., Burger H.G. The perimenopausal woman: Endocrinology and management. J. Steroid. Biochem. Mol. Biol. 2014;142:121-31.
  2. Harlow S.D., Gass M., Hall J.E., Lobo R., Maki P., Rebar R.W., Sherman S., Sluss P.M., de Villiers T.J.; STRAW + 10 Collaborative Group. Executive summary of the Stages of Reproductive Aging workshop+10: addressing the unfinished agenda of staging reproductive aging. Climacteric. 2012;15(2):105-14.
  3. Hale G.E., Manconi F., Luscombe G., Fraser I.S. Quantitative measurement of menstrual blood loss in ovulatory and anovulatory cycles in middle- and late-reproductive age and the menopausal cycle irregularity and reproductive hormone levels. Obstet. Gynecol. 2010;115(2Pt1):249.
  4. Santono N., Brown J.R., Adel T., Skurnick J.H. Characterization of reproductive hormonal dynamics in the perimenopause. J. Clin. Endocrinol. Metab. 1996;81(4):1495.
  5. Prior J.C., Hitchcock C.L. The endocrinology of perimenopause: need for a paradigm shift. Front Biosci. 2011;3:474-86.
  6. Fu P., Matthews K.A., Thurston R.C. How well do different measurement modalities estimate the number of vasomotor symptoms? Findings from the Study of Women's Health Across the Nation FLASHES Study. Menopause. 2014; 21(2):124-30.
  7. Тулупова М.С., Хамошина М.Б., Календжян А.С., Чотчаева А.И., Пастарнак А.Ю. Гинекологическая заболеваемость и репродуктивные потери в России в первой декаде XXI в. Вестн. РУДН. 2011;5:280-83.
  8. Прилепская В.Н., Межевитинова Е.А., Тагиева А.В. Внутриматочная контрацепция: руководство. М., 2000. 325 с.
  9. Sitruk-Ware R. The levonorgestrel intrauterine system for use in peri- and postmenopausal women. Contraception. 2007;75(6 Suppl):S155-60.
  10. Khamoshina M.B., Novikova T.A. The levonorg-estrel-excreting-rilizing-system «Mirena» as a method of contraceptive choice of the women with menstrual disorders. Eur. J. Contracept. Reprod. Health Care. 200813(Suppl. 2): 142-43.
  11. Андреева Е.Н., Хамошина М.Б., Цапиева Е.О. Медикаментозная терапия обильных менструаций: вчера и сегодня. Доктор. Ру. Гинекология. Эндокринология. 2013; 7(85):33-7.
  12. Андреева Е.Н., Хамошина М.Б., Сорокина А.В., Плаксина Н.Д. Эндометриоз: новые горизонты гормономодулирующей терапии. Доктор. Ру. Ч. 1. Гинекология. 2011;9(68):12-7.
  13. Здравоохранение в России, 2013. Стат. сборник. М., 2013.
  14. Радзинский В.Е. Акушерская агрессия. М., 2011. 688 с.
  15. Прилепская В.Н., Сметник В.П. Сила четвертого поколения. Перименопауза: от контрацепции к заместительной гормональной терапии. StatusPraesens. 2010;2(4):29-34.
  16. Межевитинова Е.А., Хамошина М.Б., Руднева О.Д., Иванова Е.В., Зорина Е.А. Гормональная контрацепция у женщин высокого риска: пути решения проблемы. Доктор. Ру. Гинекология. Эндокринология. 2012;1(69):27-33.
  17. Schaedel Z.E., Dolan G., Powell M.C. The use of the levonorgestrel-releasing intrauterine system in the management of menorrhagia in women with hemostatic disorders. Am. J. Obstet. Gynecol. 2005;193(4): 1361-63.
  18. Мирена внутриматочная терапевтическая система. Инструкция по применению: http:// www.rlsnet.ru.
  19. Hurskainen R., Teperi J., Rissanen P., Aalto A.M., Grenman S., Kivela A., Kujansuu E., Vuorma S., Yliskoski M., Paavonen J. Quality of life and cost-effectiveness of levonorgestrel-releasing intrauterine system versus hysterectomy for treatment of menorrhagia: a randomised trial. Lancet. 2001;357(9252): 273-77.
  20. Marjoribanks J., Lethaby A., Farquhar C. Surgery versus medical therapy for heavy menstrual bleeding. Cochrane Database Syst. Rev. 2006;lss. 2.
  21. Baldwin M.K., Jensen J.T. Contraception during the perimenopause. Maturitas. 2013;76(3):235-42.
  22. Somboonporn W., Panna S., Temtanakitpaisan T., Kaewrudee S., Soontrapa S. Effects of the levonorgestrel-releasing intrauterine system plus estrogen therapy in perimenopausal and postmenopausal women: systematic review and meta-analysis. Menopause. 2011;18(10):1060-66.
  23. Wildemeersch D. Potential health benefits of continuous LNG-IUS combined with parenteral ERT for seamless menopausal transition and beyond-- a commentary based on clinical experience.Gynecol. Endocrinol. 2013; 29(6):569-73.
  24. Management of acute abnormal uterine bleeding in non-pregnant women. Committee Opinion № 557. American College of Obstetricians and Gynecologists. Obstet. Gynecol. 2013;121(4):891-96.
  25. Singh S., Best C., Dunn S., Leyland N., Wolfman W.L.; Clinical Practice - Gynaecology Committee, Leyland N., Wolfman W., Allaire C., Awadalla A., Best C., Dunn S., Heywood M., Lemyre M., Marcoux V., Menard C., Potestio F., Rittenberg D., Singh S.; Society of Obstetricians and Gynaecologists of Canada. Abnormal Uterine Bleeding in Pre-Menopausal Women. JOGC. 2013;35(Suppl. 1):S1-28.
  26. Yoo H.J., Lee M.A., Ko Y.B., Yang J.B., Kang B.H., Lee K.H. The efficacy of the levonorgestrel-releasing intrauterine system in perimenopausal women with menorrhagia or dysmenorrhea. Arch. Gynecol. Obstet. 2012;285(1):161-66.
  27. Андреева Е.Н. Фармакоэкономическая оценка использования различных методов лечения меноррагий. Пробл. репродукции. 20114:48-55.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies