Algoritm mukoliticheskoy terapii: chto dolzhen uchityvat' pediatr
- Authors: Simonova O.I1, Gorinova Y.V1
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- Issue: No 4 (2015)
- Pages: 49-54
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/287769
- ID: 287769
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Abstract
This paper critically discusses the problem of the treatment of cough, which is a common symptom of respiratory diseases in children. The primary focus is placed on the use of ambroxol hydrochloride preparations, widely and effectively used in pediatric practice. One of these preparations Lasolvan is a strong mucolytic and surfactant synthesis stimulating agent with pronounced expectorant, antiinflammatory and antioxidant effects.Lasolvan has a variety of formulations and can be used in children, particularly in young children. The preparation is well tolerated and essentially has no side effects.
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References
- Зайцева О.В. Кашель у детей: рациональный выбор терапии. Пособие для врачей. М., 2003.
- Коровина Н.А. и др. Противокашлевые и отхаркивающие лекарственные средства в практике врача-педиатра: рациональный выбор и тактика применения. Пособие для врачей. М., 2002. 40 с.
- J. Curtis's botanical magazine. Т. 21-22. Табл. 861.
- Амелина Е.Л., Анаев Э.Х, Красовский С.А. Романова Л.К., Симонова О.И., Черняев А.Л., Чикина С.Ю. Мукоактивная терапия / Под ред. А.Г. Чучалина, А.С. Белевского. М., 2006. 128 с.
- Braga P.C. Antibiotic penetrability into bronchi-cal mucus: Pharmocokinetics and Clinical considerations. Curr. Therap. Res. 1991;49(2): 300-27.
- Wiemeyer J.C.M. Influence of ambroxol on broncho-pulmonary levels of antibiotics. Arzneim.-Forsch. Drug. Res. 1981;31(1),6:974-76.
- Beeh K.M., Beier J., Esperester A., Paul L.D. Antiinflammatory properties of ambroxol. Eur. J. Med. Res. 2008;13(12):557-62.
- Huang J, Xu J., Tian L., Zhong L. A thioredoxin reductase and/or thioredoxin system-based mechanism for antioxidant effects of ambroxol. Biochimie. 2014;97:92-103.
- Malerba M., Ragnoli B. Ambroxol in the 21st century: pharmacological and clinical update. Expert. Opin. Drug. Metab. Toxicol. 2008;4(8):1119-297.
- Heath M.F., Jacobson W. The action of lung lysosomal phospholipases on dipalmitoyl phosphatidylcholine and its significance for the synthesis of pulmonary surfactant. Pediatr Res. 1980;14:254-58.
- Eckert H., Lux M., Lachmann B. The role of alveolar macrophages in surfactant turnover. An experimental study with metabolite VIII of bromhexine (ambroxol). Lung 1983;161: 213-18.
- Cunnigham F.M., et al. Effect of Ambroxol on mucociliary transport in the guinea pig. Br. J. Pharmacol. 1983;80(Suppl.):693.
- Zhang Z.Q., Wu Q.Q., Huang X.M., Lu H. Prevention of respiratory distress syndrome in preterm infants by antenatal ambroxol: a metaanalysis of randomized controlled trials. Am. J. Perinatol. 2013;30(7):529-36.
- Bonnetti P. Ambroxol plus amoxicillin versus amoxicillin alone in various respiratory tract infections. Investig. Medica Internacional. 1993;20:99-103.
- Spatola J., et al. Influence of ambroxol on lung tissue penetration of amoxicillin. Arzneim.-Forsch. Drug. Res. 1987;37(11),8:965-66.
- Fraschini F., et al. Effects of mucolytic agent on the bioavailability of antibiotics in patients with chronic respiratory diseases. Current. Therapeutic. Research. 1988;43(4): 734-42.
- Cataldi M., Sblendorio V., Leo A., Piazza O. Biofilm-dependent airway infections: A role for ambroxol? Pulm. Pharmacol. Ther. 2014;28(2):98-108.
- Weinmann H.-M. Ambroxol in paediatrics. Therapiewoche. 1981;31:79407.
- Wauer R.R., et al. Randomised double blind trial of ambroxol for the treatment of respiratory distress syndrome. Eur. J. Paediatr. 1992;151:357-63.
- Симонова О.И., Горинова Ю.В. Ингаляционная терапия раствором амброксола (Лазолвана®): преимущества, особенности применения, эффективность. РМЖ. Педиатрия. 2014;6:1530-34.
- Таточенко В.К. Педиатру на каждый день. Справочник. М., 2012. 274 с.
- Хрущев С.В., Симонова О.И. Физическая культура детей с заболеваниями органов дыхания. Учебное пособие. М., 2006. 304 с.
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