MRSA pri infektsii protezirovannogo sustava: mishen' dlya antibakterial'noy terapii


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Abstract

The article presents the results of the monitoring of antibiotic resistance of 815 strains of Staphylococcus aureus, the leading causative agents of infectious complications after endoprosthesis replacement of hip and knee joints during 2010-2013. A comparative analysis of the activity of antibiotics depending on the resistance of Staphylococcus aureus isolates to methicillin was performed. The data on the distribution of strains of methicillin-resistant Staphylococcus aureus (MRSA) according to the minimum inhibitory concentration of vancomycin, daptomycin and ceftaroline are presented. Based on the own authors’ research and scientific literature data, analysis of potentials for the application of various antibacterial drugs for the treatment of prosthetic joint infection was performed, and the most active antibiotics against MRSA were identified.

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