Vliyanie terapii ranelatom strontsiya na iskhody lecheniya patsientov s maloenergeticheskimi perelomami lodyzhek


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Abstract

Fractures of the ankle are low-energy fractures in 20-30% of patients, and they occur in elderly and senile age. The prospective controlled randomized trial (52 patients) was aimed to the demonstration of the possibility of improving the results of surgical treatment of osteoporotic fractures of the ankle using strontium ranelate at a dose of 2 g daily for 12 months in the postoperative period. 42 patients had completed the study (group A - control [18 patients], B - main [24 patients]). All patients underwent surgery during the first 48 hours after injury in accordance with clinical guidelines. In postoperative period, both groups had received calcium supplement of 1500 mg/day, cholecalciferol 1,200 lU/day until metal structures were removed. Group B had received strontium ranelate (2.0 g once a day). Metal structures were removed in 350±15 days. According to the results of study, the use of strontium ranelate 2 g daily for a year in the postoperative period improves the functional state of the operated ankle. Subject to the conditions of use, strontium ranelate improves bone structure in the area of regenerating bone. There were no registered side effects and complications associated with the administration of strontium ranelate in this study.

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