Sindrom Kavasaki u detey: obzor literatury i analiz 22 sobstvennykh nablyudeniy


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Abstract

Kawasaki syndrome (KS) is an acute multisystem disease of unknown etiology with the development of vasculitis. For the evaluation of clinical manifestations and assessment of effectiveness of treatment, 22 patients with KS aged 2.5 months to 12 years were examined and treated. Among children hospitalized during first 10 days of illness, 25% of cases were diagnosed with partial KS; three children were diagnosed with KS only after the appearance of new symptoms and / or ineffectiveness of antibacterial therapy. In 70% of cases, the diagnosis was not in doubt on admission, as well as in case of hospitalization 10 days after onset. Single dose (2 g/kg) of intravenous immunoglobulin was effective in 77% of patients; booster dose had to be administered in 23% of cases. In young children, prolonged fever of unknown etiology requires constant awareness with regard to the KS, in order to begin specific treatment during first 10 days of illness to prevent the development of coronary artery aneurysms.

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