Immunomoduliruyushchaya terapiya genital'nogo endometrioza: realii i perspektivy primeneniya


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article presents the review of literature data on the use of various non-hormonal drugs with immunomodulating action (cytokines, tumor necrosis factor blockers, angiotenzin II receptor blockers, statins, lipoxins, natural components) for the treatment of endometriosis, both in animal models and in clinical practice.

Full Text

Restricted Access

References

  1. Сельков С.А., Ярмолинская М.И., Григорьева В.В., Аникин В.Б., Ариненко Р.Ю., Селютин А.В. Состояние антипролиферативных механизмов иммунной системы при наружном генитальном эндометриозе. Вестник Российской ассоциации акушеров-гинекологов, 1997;3:40-3.
  2. Сельков С.А., Павлов Р.В., Аксененко В.А. Использование ронколейкина в комплексной терапии генитального эндометриоза. Пособие для врачей. СПб., 2008. 84 с.
  3. Ярмолинская М.И., Тарасова М.А., Сельков С.А., Баранов В.С., Рулев В.В. Наружный генитальный эндометриоз. Пособие для врачей. СПб., 2010. 83 с
  4. Ярмолинская М.И., Тарасова М.А., Селютин А.В., Денисова В.М., Толпыгина М.Г., Сельков С.А. Патогенетическое обоснование применения иммуномодулятора «Галавит» в терапии наружного генитального эндометриоза. Журнал Российского общества акушеров-гинекологов. 2008;4:29-30
  5. Ярмолинская М.И. Роль антипролиферативных компонентов иммунной системы в патогенезе и терапии наружного генитального эндометриоза. Дисс. канд. мед. наук. СПб., 1997. 24 с.
  6. Abbas M.A., Taha M.O., Zihlif M.A., Disi A.M. β-Caryophyllene causes regression of endometrial implants in a rat model of endometriosis without affecting fertility. Eur. J.Pharmacol. 2013;702:12-9.
  7. Acien P., Perez-Albert G., Quereda F.J., Sanchez-Ferrer M., Garcia-Almela A., Velasco I. Treatment of endometriosis with transvaginal ultrasound-guided drainage under GnRH analogues and recombinant interleukin-2 left in the cysts. Gynecol. Obstet. Invest. 2005; 60:224-31.
  8. Acien P., Quereda F., Campos A., Gomez-Torres M.J., Velasco I., Gutierrez M. Use of intraperitoneal interferon α-2β therapy after conservative surgery for endometriosis and postoperativemedical treatmentwith depot gonadotropin-releasing hormone analog: a randomized clinical trial. Fertil. Steril 2002;78(4):705-11.
  9. Acien P., Quereda F.J., Gomez-Torres M.J., Bermejo R., Gutierrez M. GnRH analogues, transvaginal ultrasound-guided drainage and intracystic injection of recombinant interleukin-2 in the treatment of endometriosis. Gynecol. Obstet. Invest. 2003;55:96-104.
  10. Acien P., Velasco I., Acien M., Quereda F. Treatment of Endometriosis with Transvaginal Ultrasound-Guided Drainage and Recombinant Interleukin-2 Left in the Cysts: A Third Clinical Trial. Gynecol. Obstet. Invest. 2010;69:203-11.
  11. Bruner-Tran K.L., Osteen K.G., Duleba A.J. Simvastatin Protects against the Development of Endometriosis in a Nude Mouse Model. J. Clin. Endocrinol. Metab. 2009;94(7):2489-494.
  12. Cakmak B., Cavusoglu T., Ates U., Meral A., Nacar M.C. and Erbas O. Regression of experimental endometriotic implants in a rat model with the angiotensin II receptor blocker losartan. J. Obstet. Gynaecol. Res., 2015;41(3):601-07.
  13. Chen X.D., Ma G., Huang J.L., Chen H., Jin Y.B., Ye X.X., Hu X.J., Lin X.X. Serum-level changes of vascular endothelial growth factor in children with infantile hemangioma after oral propranolol therapy. Pediatr. Dermatol. 2013;30:549-53.
  14. Cho S., Park S.H., Choi Y.S., Seo S.K., Kim H.Y., Park K.H., Cho D.J., Lee B.S. Expression of cyclooxygenase-2 in eutopic endometrium and ovarian endometriotic tissue in women with severe endometriosis. Gynecol. Obstet. Invest. 2010;69:93-100.
  15. Ergenoglu A.M., Yeniel A.O., Erbas O., Aktug H., Yildirim N., Ulukus M., and Taskiran D. Regression of Endometrial Implants by Resveratrol in an Experimentally Induced Endometriosis Model in Rats. Reproduct. Sci. 2013;20:1230-236.
  16. Fernandes E.S., Passos G.F.,Medeiros R., daCunha F.M., Ferreira J. Campos M.M., Pianowski L.F., Calixto J.B. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur. J. Pharmacol, 2007;569:228-36.
  17. GarsideS.A., Henkin J., Morris K.D., NorvellS.M., Thomas F.H., Fraser H.M. A thrombospondinmimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre-and early-antral follicles in vivo. Endocrinology. 2010;151:5905-915.
  18. Gertsch J. Anti-inflammatory cannabinoids in diet towards abetter under- standing of CB2 receptor action. Commun.Integr. Biol. 2008;1(1):26-8.
  19. Gibra L., Maranhao R.C., Abrao M. S., Baracat E.C., Podgaec S. Could statins constitute a novel treatment for endometriosis? Systematic review of the literature. Eur. J. Obstet. & Gynecol. Reproduct. Biol. 2014;179:153-58.
  20. Greenaway J., Lawler J., Moorehead R., Bornstein P., LaMarre J., Petrik J. Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor related protein-1 (LRP-1). J. Cell Physiol. 2007;210:807-18.
  21. Hirota Y., Osuga Y., Hirata T, Harada M., Morimoto C., Yoshino O., Koga K., Yano T., Tsutsumi O., Taketani Y. Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells. Hum Reprod. 2005;20:3547-53.
  22. Hutchinson M.R., Coats B.D., Lewis S.S., Zhang Y., SprungerD.B., Rezvani N., BakerE.M., Jekich B.M., Wieseler J.L., Somogyi A.A., Martin D., Poole S., Judd C.M., Maier S.F., Watkins L.R. Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun. 2008;22(8):1178-89.
  23. Ingelmo J.M.R., Quereda F., Acien P. Effect of human interferon-alpha-2b on experimental endometriosis in rats: comparison between short and long series of treatment. Eur. J.Obstet. & Gynecol. Reproduct. Biol.2013;167:190-93.
  24. Ingelmo J.M.R., Quereda F., and Acien P. Intraperitoneal and subcutaneous treatment of experimental endometriosis with recombinant human interferon-α-2b in a murine model. Fertility and Sterility. 1999;71(5):907-11.
  25. Kaufmann R., Mussbach F., Henklein P., Settmacher U. Proteinase-activated receptor 2 mediated calcium signaling in hepatocellular carcinoma cells. J. Cancer Res. Clin. Oncol. 2011;137:965-73.
  26. Khan N., Mukhtar H. Multitargeted therapy of cancer by green tea polyphenols. Cancer Lett 2008; 269: 269-80.
  27. Koninckx P.R, Craessaerts M., Nimmerman D., Cornillie F., Kennedy S. Anti-TNF-alpha treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial. Hum Reproduction. 2008;23(9):2017-23.
  28. Kumar R., Clerc A.-C., Gori I., Russell R., Pellegrini C., Govender L Wyss., J.-C., Golshayan D., Canny G.O. Lipoxin A4 Prevents the Progression of De Novo and Established Endometriosis in a Mouse Model by Attenuating Prostaglandin E2 Production and Estrogen Signaling. PLoS ONE, 2014;9(2):e89742. doi: 10.1371/journal. pone.0089742 (Available at: http://www.ncbi. nlm.nih.gov/pmc/articles/PMC3933674/)
  29. Mariani M., Vigano P., Gentilini D., Camisa B., Caporizzo E., Di Lucia P., Monno A., Candiani M., Somigliana E., Panina-Bordignon P. The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammation. Human Reproduction, 2012;.27(7):2010-19.
  30. Mitchell S., Thomas G., Harvey K., Cottell D., Reville K, Berlasconi G., Petasis N.A., Erwig L., Rees A.J., Savill J., Brady H.R., Godson C. Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo. J. Am. Soc. Nephrol. JASN. 2002;13:2497-507.
  31. Munoz-Hernando L., Munoz-Gonzalez J., Marqueta-Marques L., Alvarez-Conejo C., Tejerizo-Garcia A., Lopez-Gonzalez G., Villegas-Munoz E., Martin-Jimenez A., SJimenez-Lopez J. Endometriosis: alternative methods of medical treatment. Intern. J. Women's Health. 2015;7:595-603.
  32. Nakamura D.S., Edwards A.K., Virani S., Thomas R., Tayade C. Thrombospondin-1 Mimetic Peptide ABT-898 Affects Neovascularization and Survival of Human Endometriotic Lesions in a Mouse Model. Am. J. Pathol. 2012;181:570-82.
  33. Quattrone F., Sanchez A.M., Pannese M., Hemmerle T., Vigano P., Candiani M., Petraglia F., Neri D., and Panina-Bordignon P. The Targeted Delivery of Interleukin 4 Inhibits Development of Endometriotic Lesions in a Mouse Model. Reproductive Sciences, 2015 1-10 (Available at: http://rsx.sagepub.com/content/early/201
  34. Ricci A.G., Olivares C.N., Bilotas M.A., Baston J.I., Singla J.J., Meresman G.F., and Baranao R.I. Natural therapies assessment for the treatment of endometriosis. Human Reproduct. 2013;28(1):178-88.
  35. Schwager K., Bootz F., Imesch P., Kaspar M., Trachsel E., Neri D. The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model. Human Reproduct. 2011;26(9):2344-52.
  36. Serhan C.N. Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins, leukotrienes, and essential fatty acids. 2005;73:141-62.
  37. Shi R.Z., Wang J.C., Huang S.H., Wang X.J., Li Q.P. Angiotensin II induces vascular endothelial growth factor synthesis in mesenchymal stem cells. Exp. Cell Res. 2009;315:10-5.
  38. Simsek Y., Gul M., Yilmaz E., Ozerol I.H., Ozerol E., Parlakpinar H. Atorvastatin exerts anti-nociceptive activity and decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-α in a rat endometriosis model. Arch. Gynecol. Obstet. 2014;290(5):999-1006
  39. Starkey E., Shahidullah H. Propranolol for infantile haemangiomas: a review. Arch. Dis. Child. 2011;96:890-93.
  40. Uzunlar O., Ozyer S., Engin-Ustun Y., Moraloglu O., Gulerman H. C., Caydere M., Keskin S.M., Mollamahmutoglu L. Effects of repeated propranolol administration in a rat model of surgically induced endometriosis. Eur. J. Obstet. & Gynecol. Reproduct. Biol. 2014; 182:167-71.
  41. Velasco I., Quereda F., Bermejo R., Campos A., Acien P. Intraperitoneal recombinant interleukin-2 activates leucocytes in rat endometriosis. J. Reprod. Immunol. 2007;74(1-2): 124-32.
  42. Wang Y., Lin M., Weng H., Wang X., Yang L., Liu F. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am. J. Obstet. Gynecol. 2014;210(6):531.e1-8.
  43. Wu M.H., Shoji Y., Wu M.C., Chuang P.C., Lin C.C., Huang M.F., Tsai S.J. Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis. Am. J. Pathol. 2005;167:1061-69.
  44. Yang J.L., Zhang C.P., Li L., Huang L., Ji S.Y., Lu C.L., Fan C.H., Cai H., Ren Y., Hu Z.Y., Gao F., Liu Y.X. Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis. Endocrinology. 2010;151:774-82.
  45. Zaveri N.T. Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci. 2006;78:2073-80.
  46. Zulfikaroglu E., Kilic S., Islimye M., Aydin M., Zergeroglu S., Batioglu S. Efficacy of anti-tumor necrosis factor therapy on endometriosis in an experimental rat model. Arch. Gynecol. Obstet. 2011;283(4):799-804.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies