No 12 (2015)

The article presents the review of literature data on the use of various non-hormonal drugs with immunomodulating action (cytokines, tumor necrosis factor blockers, angiotenzin II receptor blockers, statins, lipoxins, natural components) for the treatment of endometriosis, both in animal models and in clinical practice.

The article describes key approaches to the management of children with infection of the upper and lower urinary tract, as well as the basic principles of antibiotic therapy in this disease.

The article presents the results of prospective cohort study included 56 women aged 20-35 years with tuboperitoneal infertility, who were planned for in vitro fertilization (IVF). The main group (29 patients) received preconceptional intravaginal therapy using gel based on Dead Sea mud for 10 days from the 7-8 th day of the menstrual cycle. The control group (27 women) withdrew from physiotherapy. Intravaginal peloidotherapy reduced the incidence of chronic endometritis by 2.5 times (51.7 vs. 20.7%), increased the chances of pregnancy by 4 times (58.6 vs. 14.8%, odds ratio=4.0), increased the effectiveness of IVF by 2.7 times (40.0 vs. 14.8%), led to a spontaneous pregnancy in 9 (31.0%) patients with proximal tubal occlusion and chronic endometritis.

The article presents results of the study investigating contraceptive behaviors of 754 female students (age 14-24 years) of secondary special educational institutions of the city of Samara. It was found that a significant proportion (80%) of the respondents knows about the possibility of becoming pregnant as a result of a single (first) intercourse and that condom is a reliable means of protection against both unwanted pregnancy and HIV and other sexually transmitted diseases. Half of the girls know about daily intake of hormonal tablets; this knowledge naturally increases with the onset of sexual activity. Contraception by coitus interruptus is found to be widely spread among pupils of secondary special educational institutions; it is used by 28% of girls who have sex, even though most of them know of its unreliability. Another unreliable method of contraception - menstrual cycle contraception - is practiced by7% of sexually active girls. The authors present the data on modern combined oral contraceptives, which are the most appropriate for the young and nulliparous women from the age at menarche.

This study investigated production levels of VEGF mRNA and its receptors KDR, FLT-1, TRF1, MMP-1, MMP-7 and TIMP-2 in tissue samples of patients with different prostatic diseases. Testing VEGF production levels and KDR, FLT-1receptors, analysis of metalloproteinases and their inhibitors relationship, the role of telomeric binding protein factor-1 TRIF in clinical practice extends the feasibility of verification and differentiation of inflammatory, benign, premalignant and malignant tumors of the prostate.

Premenstrual syndrome (PMS) is a complex syndrome with protean manifestations. One of the important moments in the development of PMS is the inability of the female body to adapt to natural cyclical fluctuations of sex hormone levels. In this regard, the use of adap-togens, can be the one of the promising areas of pathogenetically substantiated pharmacological correction of PMS.

He article considers the role of omega-3 polyunsaturated fatty acids (PUFAs) in the prevention and treatment of obstetric complications. The results of several studies suggest that omega-3 fatty acids are most effective only in complex treatment of different diseases. First of all, we can be quite accurate to talk about the use of omega-3 fatty acids during pregnancy for the prevention of preterm labor, premature birth, thrombophilia, in some cases, pre-eclampsia, and allergic and chronic inflammatory diseases in children. Given the deficit of omega-3 PUFAs-rich food intake in the world and almost complete harmlessness of use of PUFAs at therapeutic doses, additional use of omega-3 PUFAs is justified for pregnant women and their children.