Omega-3 polinenasyshchennye zhirnye kisloty vo vremya beremennosti: tsifry i fakty


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

He article considers the role of omega-3 polyunsaturated fatty acids (PUFAs) in the prevention and treatment of obstetric complications. The results of several studies suggest that omega-3 fatty acids are most effective only in complex treatment of different diseases. First of all, we can be quite accurate to talk about the use of omega-3 fatty acids during pregnancy for the prevention of preterm labor, premature birth, thrombophilia, in some cases, pre-eclampsia, and allergic and chronic inflammatory diseases in children. Given the deficit of omega-3 PUFAs-rich food intake in the world and almost complete harmlessness of use of PUFAs at therapeutic doses, additional use of omega-3 PUFAs is justified for pregnant women and their children.

Full Text

Restricted Access

About the authors

A. V Murashko

Email: murashkoa@mail.ru

A. A Murashko

References

  1. Ишутина Н.А. ω-3 полиненасыщенные жирные кислоты в гомогенате плацент женщин, перенесших во время гестации обострение герпес-вирусной инфекции. Бюл. физиол. и патол. дыхания. 2011;42:64-6.
  2. Ишутина Н.А. Линолевая и арахидоновая ω-6 полиненасыщенные жирные кислоты липидов плацент женщин с герпес-вирусной инфекцией. Естествознание и гуманизм. 2011;7(1):33-5.
  3. Ишутина Н.А. Линолевая и линоленовая жирные кислоты и их роль в функционировании мембран эритроцитов при обострении герпесной инфекции в период гестации. Пробл. и персп. соврем. науки. 2011;3(1):50-1.
  4. Мозговая Е.В., Малышева О.А., Иващенко Т.Э., Айламазян Э.К. Эндотелиальная дисфункция при гестозе. СПб., 2012. 243 с.
  5. Паньшина М.В. Технология немедикаментозной профилактики преэклампсии. Вестник новых медицинских технологий. Электронное издание. 2013;1:42.
  6. Сидельникова В.М. Применение Омега-3 ПНЖК для профилактики и комплексного лечения тромбофилических нарушений при беременности. РМЖ. 2008;16(6):417-21.
  7. Ткачева О.Н., Рунихина Н.К., Чухарева Н.А., Шарашкина Н.В. Спорные вопросы артериальной гипертензии в период беременности. Фарматека. 2012;4:1-7.
  8. Bresson J.-L, Flynn A., Heinonen M., et al. DHA and support of the visual development of the unborn child and breastfed infant - Scientific substantiation of a health claim related to DHA and support of the visual development of the unborn child and breastfed infant pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA J. 2009;1006:1-12.
  9. Calvani M., Alessandri C., Sopo S.M., Panetta V., Pingitore G., Tripodi S., Zappala D., Zicari A.M. Consumption of fish, butter and margarine during pregnancy and development of allergic sensitizations in the offspring: role of maternal atopy. Pediatr Allergy Immunol. 2006;17:94-102.
  10. Carlson S.E., Colombo J., Gajewski B.J., Gustafson K.M., Mundy D., Yeast J., Georgieff M.K., Markley L.A., Kerling E.H., Shaddy D.J. DHA supplementation and pregnancy outcomes. Am. J. Clin. Nutr. 2013;97:808-15.
  11. Delgado-Noguera M.F., Calvache J.A. Bonfill Cosp X. Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development. Cochrane Database Syst. Rev. 2010;CD007901.
  12. Fidler N., Sauerwald T., Pohl A., Demmelmair H., Koletzko B. Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial. J. Lipid. Res. 2000;41:1376-83.
  13. Fritsche K. Fatty acid as modulators of the immune response. Annu. Rev. Nutr. 2006;26:45-73.
  14. Furuhjelm C.,Jenmalm M.C., Falth-Magnusson K., Duchen K. Th1 and Th2 chemokines, vaccine-induced immunity, and allergic disease in infants after maternal omega-3 fatty acid supplementation during pregnancy and lactation. Pediatr. Res. 2011;69:259-64.
  15. Furuhjelm C., Warstedt K., Fageras M., Falth-Magnusson K., Larsson J., Fredriksson M., Duchen K. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatr. Allergy. Immunol. 2011;22:505-14.
  16. Gould J.F., Smithers L.G., Makrides M. The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2013;97:531-44.
  17. Imhoff-Kunsch B., Briggs V., Goldenberg T., Ramakrishnan U. Effect of n-3 long-chain polyunsaturated fatty acid intake during pregnancy on maternal, infant, and child health outcomes: a systematic review. Paediatr. Perinat. Epidemiol. 2012;26(Suppl. 1):91-107.
  18. Imhoff-Kunsch B., Stein A.D., Martorell R., Parra-Cabrera S., Romieu I., Ramakrishnan U. Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. Pediatrics. 2011;128:505-12.
  19. Jensen C.L., Voigt R.G., Llorente A.M., Peters S.U., Prager T.C., Zou Y.L., Rozelle J.C., Turcich M.R., Fraley J.K., Anderson R.E., Heird W.C. Effects of early maternal docosahexaenoic acid intake on neuropsychological status and visual acuity at five years of age of breast-fed term infants. J. Pediatr. 2010;157:900-05.
  20. Jordan R.G. Prenatal omega-3 fatty acids: review and recommendations. J. Midwifery Womens Health. 2010;55(6):520-28.
  21. Kohlboeck G., Glaser C., Tiesler C.,Demmelmair H., Standl M., Romanos M., Koletzko B., Lehmann I., Heinrich J., LISAplus Study Group. Effect of fatty acid status in cord blood serum on children's behavioral difficulties at 10 y of age: results from the LISAplus Study. Am. J. Clin. Nutr. 2011;94:1592-99.
  22. Lee H.S., Barraza-Villarreal A., Hernandez-Vargas H., Sly P.D., Biessy C., Ramakrishnan U., Romieu I., Herceg Z. Modulation of DNA meth-ylation states and infant immune system by dietary supplementation with omega-3 PUFA during pregnancy in an intervention study. Am. J. Clin. Nutr. 2013;98:480-87.
  23. Makrides M., Gibson R.A., McPhee A.J., Yelland L., Quinlivan J., Ryan P., DOMInO Investigative Team. Effect of DHA supplementation during pregnancy on maternal depression and neuro-development of young children: a randomized controlled trial. JAMA. 2010;304:1675-83.
  24. Mozurkewich E.L., Clinton C.M., Chilimigras J.L., Hamilton S.E., Allbaugh L.J., Berman D.R., Marcus S.M., Romero V.C., Treadwell M.C., Keeton K.L., Vahratian A.M., Schrader R.M., Ren J., Djuric Z. The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. Am. J. Obstet. Gynecol. 2013;208:313.e311-313.e319.
  25. Much D., Brunner S., Vollhardt C., Schmid D., Sedlmeier E.M.,Brüderl M.,Heimberg E., Bartke N., Boehm G., Bader B.L., Amann-Gassner U., Hauner H. Effect of dietary intervention to reduce the n-6/n-3 fatty acid ratio on maternal and fetal fatty acid profile and its relation to offspring growth and body composition at 1 year of age. Eur. J. Clin. Nutr. 2013; 67:282-88.
  26. Munro I.A., Garg M.L. Prior supplementation with long chain omega-3 polyunsaturated fatty acids promotes weight loss in obese adults: a double-blinded randomized controlled trial // Food Funct. 2013; Apr 25;4(4):650-58.
  27. Noakes P.S., Vlachava M., Kremmyda L.S., Diaper N.D., Miles E.A., Erlewyn-Lajeunesse M., Williams A.P., Godfrey K.M., Calder P.C. Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo. Am. J. Clin. Nutr. 2012;95:395-404.
  28. Oken E., Kleinman K.P., Olsen S.F., Rich-Edwards J.W., Gillman M.W. Associations of seafood and elongated n-3 fatty acid intake with fetal growth and length of gestation: results from a US pregnancy cohort. Am. J. Epidemiol. 2004;160(8):774-83.
  29. Olsen S.F., Secher N.J. A possible preventative effect of lowdose fish oil on early delivery and preeclampsia: indications from a 50-year-old controlled trial. Br. J. Nutr. 1990;64(3):599-609.
  30. Olsen S.F., Osterdal M.L., Salvig J.D., Mortensen L.M., Rytter D., Secher N.J., Henriksen T.B. Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am. J. Clin. Nutr. 2008; 88:167-75
  31. Palmer D.J., Sullivan T., Gold M.S., Prescott S.L., Heddle R., Gibson R.A., Makrides M. Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial. BMJ. 2012;344:e184.
  32. Ramakrishnan U., Stein A.D., Parra-Cabrera S., Wang M., Imhoff-Kunsch B., Juarez-Marquez S., Rivera J., Martorell R. Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico. Food Nutr. Bull. 2010;31:108-16.
  33. Romieu I., Torrent M., Garcia-Esteban R., Ferrer C., Ribas-Fito N., Anto J.M., Sunyer J. Maternal fish intake during pregnancy and atopy and asthma in infancy. Clin. Exp. Allergy. 2007;37:518-25.
  34. Sausenthaler S., Koletzko S., Schaaf B., Lehmann I., Borte M, Herbarth O., von Berg A., Wichmann H.E., Heinrich J., LISA Study Group. Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age. Am. J. Clin. Nutr. 2007; 85:530-37.
  35. Steer C.D., Lattka E., Koletzko B., Golding J., Hibbeln J.R. Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age. Am. J. Clin. Nutr. 2013;98:1575-82.
  36. Szajewska H., Horvath A., Koletzko B. Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2006;83:1337-44.
  37. UrwinH.J.,MilesE.A.,NoakesP.S.,KremmydaL.S., Vlachava M., Diaper N.D., Perez-Cano F.J., Godfrey K.M., Calder P.C., Yaqoob P. Salmon consumption during pregnancy alters fatty acid composition and secretory IgA concen tration in human breast milk. J. Nutr. 2012; 142:1603-10.
  38. Warstedt K., Furuhjelm C., Duchen K., Falth-Magnusson K.,Fageras M. Theeffectsofomega-3 fatty acid supplementation in pregnancy on maternal eicosanoid, cytokine, and chemokine secretion. Pediatr. Res. 2009; 66:212-17.
  39. Willers S.M., Devereux G., Craig L.C., McNeill G., Wijga A.H., Abou El-Magd W., Turner S.W., Helms P.J., Seaton A. Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children. Thorax. 2007;62:773-79.
  40. Wojcicki J.M., Heyman M.B. Maternal omega-3 fatty acid supplementation and risk for perinatal maternal depression. J. Matern. Fetal. Neonatal. Med. 2011;24: 680-86.
  41. Кузнецова И.В. Роль полиненасыщенных жирных кислот в обеспечении здоровья матери и ребенка. Акушерство и гинекология. 2014;9:4-9.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies