Rol' progesterona i didrogesterona v terapii privychnogo nevynashivaniya beremennosti
- Authors: Belyaeva M.A1, Repina M.A1
-
Affiliations:
- Issue: No 12 (2015)
- Pages: 68-71
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/288094
- ID: 288094
Cite item
Open Access
Access granted
Abstract
The review presents the role of progesterone and dydrogesterone in the treatment of recurrent miscarriage. Comparative studies showed no significant differences in the efficacy of micronized progesterone and dydrogesterone in the treatment of spontaneous abortion. However, oral micronized progesterone was found to have lower bioavailability compared to dydrogesterone. It was demonstrated that dydrogesterone therapy reduces the risk of platelet aggregates’ formation and other mother-placenta-fetus system vascular disorders underlying preeclampsia pathogenesis.
Full Text
References
- Di Renzo G.C., Giardina I., Clerici G., Mattei A., Alajmi A.H., Gerli S. The role of progesterone in maternal and fetal medicine. Gynecol. Endocrinol. 2012;28(11):925-32.
- Di Renzo G.C., Rosati A., Mattei A., Gojnic M., Gerli S. The changing role of progesterone in preterm labour. BJOG. 2005; 112:57-60.
- Marinov B., Petkova S., Dukovski A., Georgiev G, Garnizov T., Manchev V., Kolarov G., lunakova M. Utrogestan and high risk pregnancy. Akush. Ginekol. (Sofiia).2004;43(5):22-4.
- Zainul Rashid, Lim J.F., Nawawi N.H., Luqman M., Zolkeplai M.F., Rangkuty H.S., Mohamad Nor N.A., Tamil A., Shah S.A., Tham S.W., Schindler A.E. A pilot study to determine whether progestogen supplementation using dydrogesterone during the first trimester will reduce the incidence of gestational hypertension in primigravidae. Gynecol. Endocrinol. 2014; 30(3):217-20.
- Репина М.А. Дидрогестерон - прогестаген успешной беременности. Гинекология. 2011;2(13):26-8.
- Садыкова Г.К., Гоебенкин Б.E., Семягина Л.М. Гормональная поддержка ранних сроков гестации - неожиданный барьер для преэклампсии. Медицинский альманах. 2011;6:36-8.
- Venturi G.М., Conway R.М., Steeber D.A. CD25+CD4+regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. J. Immunol. 2007; 178:291-300.
Supplementary files
