Doripenem: mikrobiologicheskie osobennosti i klinicheskie aspekty primeneniya u bol'nykh nozokomial'noy infektsiey (obzor literatury)


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Abstract

The review details the doripenem - antibiotic from the carbapenem group, registered and approved for use in the Russian Federation in 2008. Foreign publications presented convincing evidence of the clinical and microbiological efficacy of doripenem in patients with nosocomial pneumonia, including ventilator-associated pneumonia. Comparative studies demonstrate that doripenem is no less effective drug than other representatives of the carbapenem group, fluoroquinolones and inhibitor-protected penicillins in patients with complicated abdominal infections, urinary tract infections. Some studies revealed certain advantages of doripenem over other carbapenems in terms of antimicrobial activity against P. aeruginosa.

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