NSAID-INDUCED GASTROPATHIES: PATHOGENETICALLY SUBSTANTIATED APPROACHES TO PREVENTION AND THERAPY


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Abstract

Non-steroidal anti-inflammatory drug-induced gastropathy (NSAID-gastropathy) often occurs in clinical practice due to wide use of this group of drugs. Currently, the most common of the therapeutic strategies applied considered are combination of NSAIDs with proton pump inhibitors, and the use of selective cyclooxygenase-2 inhibitors. The introduction of the new drug with proven effect, rebamipide, having a gastroprotective action by increasing the production of endogenous prostaglandins, opens up new prospects for management of this difficult group of patients in clinical practice.

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About the authors

I. V Maev

SBEI HPE MSMSU n.a. A.I. Evdokimov of RMPH

Moscow

D. N Andreev

SBEI HPE MSMSU n.a. A.I. Evdokimov of RMPH

Email: dna-mit8@mail.ru
Teaching Assistant of the Department of Propedeutics of Internal Diseases and Gastroenterology Moscow

D. T Dicheva

SBEI HPE MSMSU n.a. A.I. Evdokimov of RMPH

Moscow

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