IVF/ICSI OUTCOMES IN WOMEN WITH OBESITY AND METABOLIC SYNDROME


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article describes the results of the retrospective application of in vitro fertilization/intracytoplasmic sperm injection in 31 female patients with a body mass index> 25 kg/m2 (38 stimulation cycles) compared to a control group of 20 patients with normal body weight. Indications for the use of assisted reproductive technology included tubal-peritoneal infertility due to obstruction or lack of uterine tubes or male infertility. The features of superovulation stimulation and clinical outcomes were accessed, as well as the frequency of ovarian hyperstimulation syndrome, depending on the presence of obesity, type of fat deposits, the presence of the metabolic syndrome and polycystic ovary syndrome.

Full Text

Restricted Access

About the authors

N. M Podzolkova

SBEI FPE “Russian Medical Academy of Postgraduate Education» of RMPH Moscow

Yu. A Koloda

Email: julkol@yandex.ru
SBEI FPE “Russian Medical Academy of Postgraduate Education» of RMPH Department of Obstetrics and Gynecology Moscow

M. B Anshina

SBEI FPE “Russian Medical Academy of Postgraduate Education» of RMPH Moscow

O. L Glazkova

SBEI FPE “Russian Medical Academy of Postgraduate Education» of RMPH Moscow

References

  1. Беляков Н.А., Сеидова Г.Б., Чубриева Н.В., Глухов Н.В. Метаболический синдром у женщин. СПб., 2005. 440 с.
  2. Бутрова С.А. Метаболический синдром: патогенез, клиника. Диагностика, подходы к лечению. РМЖ. 20012;9(2):56-60.
  3. Леонов Б.В., Финогенова Е.Я., Козлова А.Ю. Фоллитропин-бета в лечении бесплодия методами вспомогательной репродукции. Проблемы репродукции. 2005;5:5-11.
  4. Ожирение: этиология, патогенез, клинические аспекты/ Под ред. И.И. Дедова, Г.А. Мельниченко. М., 2004. 449 с.
  5. Петунина Н.А. Современные подходы к лечению ожирения. Consilium medicum. 2002;4(1).
  6. Синдром гиперандрогении у женщин. Сост. И.И. Дедов, Е.Н. Андреева, А.А. Пищулин, Е.А. Карпова. М., 2006. 40 с.
  7. Синдром поликистозных яичников / Под ред. И.И. Дедова, Г.А. Мельниченко. М., 2007. 242-72.
  8. Al-Inany H., Aboulghar M. GnRH antagonist in assisted reproduction: a Cochrane review. Hum. Reprod. 2002;17:874-85.
  9. Al-Inany H.G., Abou-Setta A.M., Aboulghar M. Gonadotrophin-releasing hormone antagonists for assisted conception: a Cochrane review. Reprod. Biomed. Online. 2007;14(5):640-49.
  10. Awartani K.A., Nahas S., Al Hassan S.H. Infertility treatment outcome in sub groups of obese population. Reprod. Biol. Endocrinol. 2009;27(7):52.
  11. Balen A.H., Platteau P., Andersen A.N., Devroey P., Sorensen P., Helmgaard L., Arce J.C. The influence of body weight on response to ovulation induction with gonadotrophins in 335 women with World Health Organization group II anovulatory infertility. BJOG. 2006;113(10):1195-202. Epub 2006.
  12. Barbieri R.L., Smith S., Ryan K.J. The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism. Fertil. Steril. 1988; 50:197-212.
  13. Bradley J., In Vitro Fertilization. N. Engl. J. Med. 2007;356:379-86.
  14. Clark A.M., Thornley B., Tomlinson L., Galletley C., Norman R.J. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum. Reprod. 1998;13:1502-505.
  15. Consensus on infertility treatment related to polycystic ovary syndrome. The Thessaloniki ESHRE/ ASRM-Sponsored PCOS Consensus Workshop. Human. Reproduction. 2008;23(3):462-77.
  16. Diamanti-Kandarakis E., Bergiele A. The influence of obesity on hyperandrogenism and infertility in the female. Obes. Rev. 2001; 2(4):231-38.
  17. Dobbelsteyn C.J., Joffres M.R., MacLean D.R., Flowerdew G. A comparative evaluation of waist circumference, waist-to-hip ratio and body mass index as indicators of cardiovascular risk factors: the Canadian Heart Health Surveys. Int. J. Obes. Relat. Metab. Disord. 2001; 25:652-61.
  18. Dokras A., Baredziak L., Blaine J., Syrop C., VanVoorhis B.J., Sparks A. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet. Gynecol. 2006;108(1):61-9.
  19. Fedorcsak P., Dale P.O., Storeng R., Ertzeid G., Bjercke S., Oldereid N., Omland A.K., Abyholm T., Tanbo T. Impact of overweight and underweight on assisted reproduction treatment. Hum. Reprod. 2004;19:2523-28.
  20. Ferlitsch K., Sator M.O., Gruber D.M., Rucklinger E., Gruber C.J., Huber J.C. Body mass index, follicle-stimulating hormone and their predictive value in in vitro fertilization. J. Assist. Reprod. Genet. 2004;21(12):431-36.
  21. Franks S. Polycystic ovary syndrome. New Engl. J. Med. 1995;333:853-61.
  22. Fulghesu A.M., Villa P., Pavone V., et al. The impact of insulin secretion on the ovarian response to exogenous gonadotropins in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 1997;82:644-48.
  23. Gambineri A., Pelusi C., Vicennati V., Pagotto U., Pasquali R. Obesity and the polycystic ovary syndrome. Int. J. Obes. Rel. Metab. Disord. 2002;26:883-96.
  24. Koloszar S., Daru J., Kereszturi A., Zavaczki Z., Szollosi J., Pal A. Effect of female body weight on efficiency of donor AI. Arch. Androl. 2002;48:323-27.
  25. Lake J.K., Power C., Cole T.J. Women's reproductive health: the role of body mass index in early and adult life. Int. J. Obes. Relat. Metab. Disord. 1997;21:432-38.
  26. Lashen H., Ledger W., Bernal A.L., Barlow D. Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization. Hum. Reprod. 1999;14:712-15.
  27. Lintsen A.M., Pasker-de Jong P.C., de Boer E.J., Burger C.W., Jansen C.A., Braat D.D., et al. Effects of subfertility cause, smoking and body weight on the success rate of IVF. Hum. Reprod. 2005;20:1867-75.
  28. Loh S., Wang J.X., Matthews C.D. The influence of body mass index, basal FSH and age on the response to gonadotrophin stimulation in non-polycystic ovarian syndrome patients. Hum. Reprod. 2002;17:1207-11.
  29. Maheshwari A., Scotland G., Bell J. The direct health services costs of providing assisted reproduction services in overweight or obese women: a retrospective cross-sectional analysis Hum. Reprod. 2009;24:633-39.
  30. Maheshwari A., Stofberg L., Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology - a systematic review Hum. Reprod. Update. 2007;13(5):433-44.
  31. Styne-Gross A., Elkind-Hirsch K., Scott R.T. Jr. Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation Fertil. Steril. 2005;83(6):1629-34.
  32. Tamer Erel C., Senturk L.M. The impact of body mass index on assisted reproduction. Curr. Opin. Obstet. Gynecol. 2009;21(3):228-35.
  33. Tanbo T. The role of body weight on the outcome of assisted reproduction. In Filicori M (ed.) Advances in infertility treatment. Monduzzi Editore, Bologna, Italy. 2002. 191-201.
  34. Wang J.X., Davies M., Norman R.J. Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study. BMJ. 2000;321:1320-21.
  35. Wittemer C., Ohl J., Bailly M., Bettahar-Lebugle K., Nisand I. Does body mass index of infertile women have an impact on IVF procedure and outcome? J. Assist. Reprod. Genet. 2000;17:547-52.
  36. Zachariah M., Fleming R., Acharya U. Management of obese women in assisted conception units: a UK survey. Hum. Fertil. (Camb). 2006;9(2):101-5.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies