OXIDATIVE STRESS AND PLACENTAL ANTIOXIDANT DEFENSE ENZYME GENES EXPRESSION IN PREECLAMPSIA


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Abstract

The article presents the results of evaluation of the level of oxidative stress and antioxidant defense enzyme genes expression in preeclampsia (PE) with the participation of 31 pregnant women. All patients were divided into 2 groups: group I (main group) consisted of 11 pregnant women with PE, group II (control group) - 20 healthy pregnant women. It is shown that PE is accompanied by increased levels of oxidative stress and glutathione-1and glutathione reductase genes expression in the placenta.

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About the authors

P. A Khovkhaeva

FSBI “Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Acad. V.I. Kulakov" of RMPH Moscow

N. V Tyutyunnik

Email: v_tioutiounnik@oparina4.iu
FSBI “Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Acad. V.I. Kulakov" of RMPH MD, Head of Physiological Obstetric Department Moscow

A. M Krasny

FSBI “Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Acad. V.I. Kulakov" of RMPH Moscow

O. A Sergunina

FSBI “Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Acad. V.I. Kulakov" of RMPH Moscow

L. A Timofeeva

FSBI “Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Acad. V.I. Kulakov" of RMPH Moscow

N. E Kan

FSBI “Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Acad. V.I. Kulakov" of RMPH Moscow

V. L Tyutyunnik

FSBI “Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Acad. V.I. Kulakov" of RMPH Moscow

References

  1. Redman C.W., Sargent I.L. Pre-eclampsia, the placenta and the maternal systemic inflammatory response - a review. Placenta. 2003;24(Suppl. A):21-7.
  2. Redman C.W., Sargent I.L. Placental stress and pre-eclampsia: a revised view. Placenta. 2009;30(Suppl. A):38-42.
  3. Myatt L., Cui X. Oxidative stress in the placenta. Histochem. Cell. Biol. 2004;122(4):369-82.
  4. Burton G.J., Yung H.W., Cindrova-Davies T., Charnock-Jones D.S. Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia. Placenta. 2009;30(Suppl. A):43-8.
  5. Stehbens W.E. Oxidative stress in viral hepatitis and AIDS. Exp. Mol. Pathol. 2004; 77(2):121-32.
  6. Iskusnykh I.Y., Popova T.N., Agarkov A.A., Pinheiro de Carvalho M.A., Rjevskiy S.G. Expression of glutathione peroxidase and glutathione reductase and level of free radical processes under toxic hepatitis in rats. J. Toxicol. 2013;2013:870628.
  7. Hubel C.A., Roberts J.M., Taylor R.N., Musci T.J., Rogers G.M., McLaughlin M.K. Lipid peroxidation in pregnancy: new perspectives on preeclampsia. Am. J. Obstet. Gynecol. 1989;161(4):1025-34.
  8. Sandstrom P.A., Mannie M.D., Buttke T.M. Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J. Leukoc. Biol. 1994;55(2):221-26.
  9. Can M., Guven B., Bektas S., Arikan I. Oxidative stress and apoptosis in preeclampsia. Tissue Cell. 2014;46(6):477-81.
  10. Lappas M., Mitton A., Peermezel M. In response to oxidative stress, the expression of inflammatory cytokines and antioxidant enzymes are impaired in placenta, but not adipose tissue, of women with gestational diabetes. J. Endocrinol. 2010;204(1):75-84.

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