APPLICATION OF SAXAGLIPTIN AND ITS COMBINATION WITH METFORMIN IN THE THERAPY OF TYPE 2 DIABETES MELLITUS IN ELDERLY PATIENTS


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Abstract

The article discusses the features of the course of diabetes mellitus (DM) in elderly patients, hypoglycemic therapy in which has its own characteristics. The use of antidiabetic drugs with a minimum dose frequency during the day and a low risk of side effects - nephrotoxicity, hepatotoxicity and hypoglycemia - is an important principle of treatment of such patients. Prospects of use of dipeptidyl peptidase-4 inhibitor saxagliptin in elderly patients with type 2 diabetes are considered. Currently, there are 6 international, placebo-controlled studies of efficacy and safety of this drug in DM2 patients over age 65 years. Their results suggest that the therapy with saxagliptin and combination of saxagliptin+metformin in elderly DM2 patients is is sufficiently safe and effective in relation to the risk of hypoglycaemia and cardiovascular events.

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M. B Antsiferov

SBHCI Endocrinological Dispensary of Moscow Healthcare Department MD, Prof., Chief Physician

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