EXPERIENCE OF USE OF OMEGA-3 POLYUNSATURATED FATTY ACIDS IN THE INTEGRATED PREVENTION OF PREECLAMPSIA (GESTOSIS) IN PREGNANT WOMEN


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The efficacy of use of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) in comprehensive prevention of gestosis (preeclampsia) in pregnant women with extragenital pathology and treatment of mild to moderate gestosis in cases of any contraindications for the appointment of antiplatelet and anticoagulant therapy was evaluated. It was found that long-term use of the ω-3 PUFAs from 1 trimester contributes to the normalization of hemostasis and significantly reduces the frequency and severity of gestosis in high risk group of pregnant women. Addition of the ω-3 PUFAs to the complex therapy of mild to moderate gestosis significantly improves pregnancy outcomes for the fetus.

Full Text

Restricted Access

About the authors

E. V Mozgovaya

FSBIS SRIOGP n.a. D.O. Ott; SBEI HPE St. Petersburg State University

Email: elmozg@mail.ru

R. N Rzaeva

FSBIS SRIOGP n.a. D.O. Ott

References

  1. Айламазян Э.К., Мозговая Е.В. Гестоз: теория и практика. М., 2008. 272 с.
  2. Громова О.А.,Торшин И.Ю., Лиманова О.А., Серов В.Н. О профилактической, лечебной и избыточной дозе омега-3 полиненасыщенных жирных кислот в прегравидарный период, во время беременности и кормления грудью. Эффективная фармакотерапия. Акушерство и гинекология. 2014; №4(45).
  3. ГромоваО.А,ТоршинИ.Ю,СухихГ.Т,Баранов А.А., Прилепская В.Н., Тетруашвили Н.К., Уварова Е.В. Роли различных форм омега-3 ПНЖК в акушерстве и неонатологии. Национальный проект «Здоровье». М., 2009.
  4. Кошелева Н.Г., Аржанова О.Н., Комаров Е.К. Применение препаратов магния при сочетанных формах гестоза, профилактика и лечение. 2012. 36 с.
  5. Ребров В.Г., Громова О.А. Витамины, макро-и микроэлементы. М., 2008. 960 с.
  6. Серов В.Н., Ветров В.В., Воинов В.А. Преэклампсия. СПб., 2011.
  7. Соколян А.В. Роль ангиогенных факторов роста в прогнозировании акушерской патологии у беременных. Дисc. канд. мед. наук. М., 2009. 139 с.
  8. Ходжаева З.С., Холин А.М., Вихляева Е.М. Ранняя и поздняя преэклампсия: парадигмы патобиологии и клиническая практика. Акушерство и гинекология. 2013;10:4-11.
  9. Bezerra M.S. E Moura H., Marques Lopes L., Murthi P., da Silva Costa F. Prevention of Preeclampsia. J Pregnancy. 2012;2012: 435090.
  10. Bujold E., Roberge S., Lacasse Y. Bureau M., Audibert F., Marcoux S., Forest J.C., Giguеre Y. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstet. Gynecol. 2010;116(2):402-14.
  11. Dekker G., Sibai B. Primary, secondary, and tertiary prevention of pre-eclampsia. Lancet. 2001;357(9251):209-15.
  12. Maynard S. E., Min J. Y., Merchan J., Lim K.H., Li J., Mondal S., Libermann T.A., Morgan J.P., Sellke F.W., Stillman I.E., Epstein F.H., Sukhatme V.P., Karumanchi S.A. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction hypertension, and proteinuria in preeclampsia. J. Clin. Investigat. 2003;111(5):649-58.
  13. Schmidt M., Dogan C., Birdir C., Kuhn Ul., Gellhaus Al. Rainer, Kasimir-Bauer S.: Placental Growth Factor: A Predictive Marker for Preeclampsia? Gynakologisch-geburtshilfliche Rundschau. 2009;49(2):94-99.
  14. Sibai B.M. Diagnosis, prevention, and management of eclampsiaю Obstet. Gynecol. 2005;105(2):402-10.
  15. WHO. Risking death to give life. World Health Organization, Geneva, Switzerland, 2005.
  16. Zainul Rashid M.R., Lim J.F., Nawawi N.H., Luqman M., et al. A pilot study to determine whether progestogen supplementation using dydrogesterone during the first trimester will reduce the incidence of gestational hypertension in primigravidae. Gynecol. Endocrinol. 2014;30(3):217-220.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies