THE ROLE OF MICROSATELLITE INSTABILITY IN AMPULLAR CARCINOMA


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Ampullary carcinomas (AC) include tumors in the distal common bile duct and/ or the ampullary part of the main pancreatic duct and major duodenal papilla. AC accounts for 0.5% of all cancers of the gastrointestinal tract. AC is characterized by the highest rates of 5-year survival (70%) and low recurrence rate. According to the literature, many authors include AC in the group of tumor with hereditary nonpolyposis colorectal cancer syndrome, which are characterized by a high frequency of microsatellite instability (MSI) due to the presence of germinal mutations in the MSH2, MLH1, PMS2, MSH3, MSH6 and MLH3 genes. The aim of this work was to evaluate the frequency and clinical and biological value of MSI in AC. The work is based on the operating material obtained from 31 patients with AC, who were treated in Moscow institutions in 2003-2015. The study showed that MSI in AC is present in 16.7% of sporadic carcinomas, and is characteristic of tumors with intestinal immunophenotype, and is met with about the same frequency as in colorectal carcinoma. In the only case detected, high level MSI with the loss of DNA repair proteins can be regarded as a predictive factor of hereditary cancer.

Full Text

Restricted Access

About the authors

O. V Paklina

SBHCI CCH n.a. S.P. Botkin of the Moscow Healthcare Department; SBHCI Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

G. R Setdikova

SBHCI CCH n.a. S.P. Botkin of the Moscow Healthcare Department

A. S Daabul

SBHCI CCH n.a. S.P. Botkin of the Moscow Healthcare Department

V. P Shubin

FSBI “State Research Center of Coloproctology n.a. A.N. Ryzhikh"

N. I Pospekhova

FSBI “State Research Center of Coloproctology n.a. A.N. Ryzhikh"

D. L Rotin

SBHCI Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

Email: d.rotin@mknc.ru
MD, Head of the Pathoanatomical Department

References

  1. Adsay V.,Ohike N, TajiriT.,Kim G.E.,Krasinskas A., Balci S., Bagci P., Basturk O., Bandyopadhyay S., Jang K.T., Kooby D.A., Maithel S.K., Sarmiento J., Staley C.A., GonzalezR.S., Kong S.Y., Goodman M. Ampullary Region Carcinomas. Definition and Site Specific Classification With Delineation of Four Clinicopathologically and Prognostically Distinct Subsets in an Analysis of 249 Cases. Am. J. Surg. Pathol. 2012;36(11): 1592-608.
  2. Kim R.D., Kundhal P.S., McGilvray I.D., Cattral M.S., Taylor B., Langer B., Grant D.R., Zogopoulos G., Shah S.A., Greig P.D., Gallinger S. Predictors of failure after pancreaticoduodenectomy for ampullary carcinoma. J. Am. Coll. Surg. 2006;202:112-19.
  3. Kimura W., Futakawa N., Zhao B. Neoplastic diseases of the papilla of Vater. J. Hepatobiliary Pancreat. Surg. 2004;11:223-31.
  4. Паклина О.В., Кармазановский Г.Г., Сетдикова Г.Р. Патоморфологическая и лучевая дигностика хирургических заболеваний поджелудочной железы. М., 2013. 181 с.
  5. Achille A., Baron A., Zamboni G., Di Pace C., Orlandini S., Scarpa A. Chromosome 5 allelic losses are early events in tumours of the papilla of Vater and occur at sites similar to those of gastric cancer. Br. J. Cancer. 1998;78:1653-60.
  6. Moore P.S., Orlandini S., Zamboni G., Capelli P., Rigaud G., Falconi M., Bassi C., Lemoine N.R., Scarpa A. Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. Br. J. Cancer. 2001;84:253-62.
  7. Nakata B., Wang Y.Q., Yashiro M., Nishioka N., Tanaka H., Ohira M., Ishikawa T., Nishino H., Hirakawa K. Prognostic value of microsatellite instability in resectable pancreatic cancer. Clin. Cancer Res. 2002;8:2536-40.
  8. Lin K.M., Shashidharan M., Thorson A.G., Ternent C.A., Blatchford G.J., Christensen M.A., Watson P. Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer. J. Gastrointest. Surg. 1998;2:67-71.
  9. Boland C.R., Thibodeau S.N., Hamilton S.R., Sidransky D.,Eshleman J.R.,Burt R.W., Meltzer S.J., Rodriguez-Bigas M.A., Fodde R., Ranzani G.N., Srivastava S. A National CancerInstitute Workshop on Microsatellite Instability for cancer detectionand familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998;58:5248-57.
  10. Кулигина Е.Ш., Соколенко А.П., Григорьев М.Ю. и др. Анализ RER+ фенотипа в билатеральных и монолатеральных карциномах молочной железы. Сибирский онкологический журнал. 2008;2:55-61.
  11. Imai Y., Tsurutani N., Oda H., Inoue T., Ishikawa T. Genetic instability and mutation of the TGF-beta-receptor-II gene in ampullary carcinomas. Int. J. Cancer. 1998;76:407-11.
  12. Scarpa A., Di Pace C., Talamini G., Falconi M., Lemoine N.R., Iacono C., Achille A., Baron A., Zamboni G. Cancer of the ampulla of Vater: chromosome 17p allelic loss is associated with poor prognosis. Gut. 2000;46:842-48.
  13. Suto T., Habano W., Sugai T., Uesugi N., Kanno S., Saito K., Nakamura S. Infrequent microsatellite instability in biliary tract cancer. J. Surg. Oncol. 2001;76:121-26.
  14. Rashid A., Ueki T., Gao Y.T., Houlihan P.S., Wallace C., Wang B.S., Shen M.C., Deng J., Hsing A.W. K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a populationbased study in China. Clin. Cancer Res. 2002;8:3156-63.
  15. Park S., Kim S.W., Kim S.H., Lee B.L., Kim W.H. Loss of heterozygosity in ampulla of Vater neoplasms during adenoma-carcinoma sequence. Anticancer Res. 2003;23:2955-59.
  16. Ruemmele P., Dietmaier W., Terracciano L., Tornillo L., Bataille F., Kaiser A., Wuensch P.H., Heinmoeller E., Homayounfar K., Luettges J., Kloeppel G., Sessa F., Edmonston T.B., Schneider-Stock R., Klinkhammer-Schalke M., Pauer A., Schick S., Hofstaedter F., Baumhoer D., Hartmann A. Histopathologic Features and Microsatellite Instability of Cancers of the Papilla of Vater and Their Precursor Lesions. Am. J. Surg. Pathol. 2009;33:691-704.
  17. Паклина О.В., Сетдикова Г.Р. Вестник ВГМУ. 2015;3(55):121-28.
  18. Umar A., Boland C.R., Terdinam J.P., Syngal S., de la Chapelle A., Rüschoff J., Fishel R., Lindor N.M., Burgart L.J., Hamelin R., Hamilton S.R., Hiatt R.A., Jass J., Lindblom A., Lynch H.T., Peltomaki P., Ramsey S.D., Rodriguez-Bigas M.A., Vasen H.F., Hawk E.T., Barrett J.C., Freedman A.N., Srivastava S. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J. Natl. Cancer Inst. 2004; 96:261-68.
  19. Bosman F.T. WHO Classification of tumors of the digestive system Lyon, 2010.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies