EFFECT OF DISTRIBUTION OF GLYCINE RECEPTORS ON THE POSTSYNAPTIC MEMBRANE OF NEURONS ON THE CONCENTRATION GRADIENT OF CHLORIDE IONS
- Authors: Nartsissov Y.R1, Boronovsky S.E1, Mashkovtseva E.V1, Kopylova V.S1
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Affiliations:
- Institute of Cytochemistry and Molecular Pharmacology
- Issue: No 10 (2016)
- Pages: 35-39
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289029
- ID: 289029
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Abstract
Glycine is a well known neurotransmitter of the central nervous system. Inhibitory effect of this amino acid is based on the activation of specific glycine receptor (GlyR), which is a ligand-dependent chloride channel on the surface of the neuronal membrane. It is known that change in the number of receptors on neuronal membrane represents an important aspect of neuroplasticity. However, the role of spatial location of receptors on the surface the membrane is not fully understood. The aim of this work was to evaluate the effect of the relative distribution of GlyR on postsynaptic on the membrane surface on the formation of the spatial gradient of chloride ions into the neuronal endings. To achieve this aim, computer modeling of nonsteady concentration gradients of chloride ions occurring near the postsynaptic membrane of the glycinergic synapse after the opening of glycine receptor channels was performed. For modeling of human postsynaptic neuronal ending, virtual scaled phantom was used. It is shown that predominant localization of GlyR in the central part of the postsynaptic membrane leads to stable increased concentration of chloride ions compared with synapses with stochastic or peripheral distribution of receptors. The spatial distribution of the receptors on the postsynaptic membrane, along with their number, determines the amplitude of local variation of the ion concentration in the neuron.
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About the authors
Ya. R Nartsissov
Institute of Cytochemistry and Molecular Pharmacology
Email: yarosl@biotic.dol.ru
PhD in Physical and Mathematical Sciences, Associate Professor Moscow
S. E Boronovsky
Institute of Cytochemistry and Molecular PharmacologyMoscow
E. V Mashkovtseva
Institute of Cytochemistry and Molecular PharmacologyMoscow
V. S Kopylova
Institute of Cytochemistry and Molecular PharmacologyMoscow
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