SELECTION OF INTERFERON INDUCERS FOR SICKLY CHILDREN


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This article proposes a review of modern conceptions of interferons (IFNs) as the key element that determines the interaction of natural and adaptive immunity, their importance in antiviral defense of cells and the organism as a whole, and literature data on the value of interferon status in children, characteristics of interferon status in frequently ill children (FIC), as well as results of own authors’ examination of SC group - the degree of IFN-α and IFN-γ deficiency and humoral immunity. The study revealed IFN system deficiency alone in 66% of SC group, and violation of humoral immunity in combination with IFN system deficiency in 34% of FIC group. At the same time, only IFN system failure was revealed in all occasionally ill children, and indicators of humoral immunity were within normal limits. Choice of interferon inducers is demonstrated based on individual sensitivity of leukocytes. A number of drugs that are recommended for use in pediatric patients for the correction of identified violations were considered.

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作者简介

M. Savenkova

SBEI HPE RSMU

MD, Prof. at the Department of Clinical Functional Diagnostics Moscow

O. Karashtina

Polyclinic of OJSC «Gazprom»

Moscow

M. Shabat

Polyclinic of OJSC «Gazprom»

Moscow

G. Kraseva

Polyclinic of OJSC «Gazprom»

Moscow

N. Abramova

Polyclinic of OJSC «Gazprom»

Moscow

T. Kraseva

Polyclinic of OJSC «Gazprom»

Moscow

参考

  1. Isaacs A., Lindemann J. Virus Interference. I The interferon. Proc.R. Soc., Lond. B. Biol Sci. 1957;147(927):258-67.
  2. Isaacs A., Lindemann J., Valentite R.C. Virus Interference. II. Some properties of interferon. Proc. R. Soc., Lond. B. Biol Sci. 1957;147(927):268-73.
  3. Hertzog P., Forster S., Samarajiwa S. Systems biology of interferon responses. J. of Interferon and Cytokine Res. 2011;31(1):5-11.
  4. Branca A.A., Baglioni C. Evidence that types I and II interfferons have different receptors. Nature. 1981;294(5843):768-70.
  5. Weissmann C., Nagata S., Boll W., Fountoulakis M., Fujisawa A., Fujisawa J.I., Haynes J., Henco K., Mantei N., Ragg H., Schein C., Schmid J., Shaw G., Streuli M., Taira H., Todokoro K., Weidle U. Structure and expression of human IFN-alpha genes. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 1982;299(1094):7-28.
  6. Golovleva I., Kandefer-Szerszen M., Beckman L., Lundgren E. Polymorphism in the interferon-a gene family. Am. J. Hum. Genet. 1996; 57:570-78.
  7. Ohno S., Taniguchi T. Structure of a chromosomal gene for human interferon beta. Proc. Natl. Acad. Sci. USA. 1981;78(9):5305-309.
  8. Gross G., Mayr U., Bruns W., Grosveld F., Dahl H-H.M., Collins J. The structure of thirty-six kilobase region of the human chromosome including the fibroblat interferon gene IFN-β. Nucleic Acids Research. 1981;9(11): 2495-507.
  9. LaFleur D.W., Nardelli B., Tareeva T., Mather D., Feng P., Semenuk M., Taylor K., Buergin M., Chinchilla D., Roshke V., Chen G., Ruben S.M., Pitha P.M., Coleman T.A., Moore P.A. Interferon-к, a novel type I interferon expressed in human keratinocytes. J. Biol. Chem. 2001;276(43):39765-71.
  10. Xi Y., Day S.L., Jackson R.J., Ranasinghe Ch. Role of novel type interferon epsilon in viral infection and mucosal immunity. Nature. Mucosal Immunology. 2012;5(6):610-22.

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