EXPERIENCE OF USE OF ANTIEMETIC AGENTS IN ACUTE GASTROENTERITIS IN CHILDREN


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Abstract

The results of the use of antiemetics, potent selective serotonergic 5-HT3 receptor antagonists, in children with rotavirus infection are presented. The data showed benefit of the use of these antiemetic drugs in view of reducing the need for intravenous rehydration for children with acute rotavirus gastroenteritis. Ondansetron is a safe and effective anti-emetic drug which can be used from age of 1 month. Reduced need for intravenous rehydration after receiving ondansetron shortens the duration of hospitalization, and thereby reduces the overall cost of treatment.

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About the authors

T. V Vilchanskaya

FSAI “Scientific Center of Children's Health" of RMH

Email: tatiana_garats@inbox.ru
pediatrician, post-graduate student at the Department of Diagnosis and Rehabilitation Treatment Moscow

M. D Bakradze

FSAI “Scientific Center of Children's Health" of RMH

Moscow

V. K Tatochenko

FSAI “Scientific Center of Children's Health" of RMH

Moscow

References

  1. Levine D.A. Antiemetics for acute gastroenteritis in children. Current Opinion in Pediatrics. 2009;21(3):294-98.
  2. Adekoya N. Reasons for visits to emergency departments for Medicaid and State Children's Health Insurance Program patients: United States, 2004. North Carolina Med. J. 2010; 71(2):123-30.
  3. Northrup R.S., Flanigan T.P Gastroenteritis. Pediatr. Rev. 1994;15:461-72.
  4. King C.K., Glass R., Bresee J.S., Duggan C. Centres for Disease Control and Prevention. Managing acute gastroenteritis among children: Oral rehydration, maintenance and nutritional therapy. MMWR Recomm. Rep. 2003;52:1-16.
  5. Motamedifar M., Amini E., Shirazi P.T. Frequency of Rotavirus and Adenovirus Gastroenteritis Among Children in Shiraz, Iran. Iranian Red Crescent Med. J. 2013;15(8):729-33.
  6. Kan K.K., Jones R.L., Ngan M.P, Rudd J.A., Wai M.K. Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew). Eur. J. Pharmacol. 2003;482(1-3):297-304.
  7. Guarino A., Albano F., Ashkenazi Sh., Gendrel D., Hoekstra H., Shamir R., Szajewska H. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition/European Society for Paediatric Infectious Diseases Evidence-based Guidelines for the Management of Acute Gastroenteritis in Children in Europe. J. Pediatr. Gastroenterol. Nutr. 2008;46:S81-S184.
  8. Guarino A., Ashkenazi Sh., Gendrel D., Lo Vecchio A., Shamir R., Szajewska H. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases Evidence-Based Guidelines for the Management of Acute Gastroenteritis in Children in Europe: Update 2014. J. Pediatr. Gastroenterol. Nutr. 2014;59:132-52.
  9. Jürgens H., McQuade B. Ondansetron as prophylaxis for chemotherapy and radiotherapy-induced emesis in children. Oncology 1992;49:279-85.
  10. Lippens R.J., Broeders G.C. Ondansetron in radiation therapy of brain tumor in children. Pediatr. Hematol. Oncol. 1996;13:247-52.
  11. Glass R.I., Lew J.F., Gangarosa R.E., LeBaron C.W., Ho M.S. Estimates of morbidity and mortality rates for diarrheal diseases in American children. J. Pediatr. 1991;118:S27-33.
  12. Domino K.B., Anderson E.A., Polissar N.L., Posner K.L. Comparative efficacy and safety of ondansetron, droperidol and metoclopramide for preventing postoperative nausea and vomiting: A meta-analysis. Anesth. Analg. 1999; 88:1370-79.
  13. Splinter W.M., Rhine E.J., Roberts D.W., et al. Ondansetron is a better prophylactic antiemetic than droperidol for tonsillectomy in children. Can. J. Anaesth. 1995;42:848-51.
  14. DeCamp L.R., Byerley J.S., Doshi N., Steiner M.J. Use of antiemetic agents in acute gastroenteritis: a systematic review and meta-analysis. Arch. Pediatr. Adolesc. Med. 2008;162(9):858-65.
  15. Evidence-based care guideline for prevention and management of acute gastroenteritis (AGE) in children aged 2 months to 18 years. 1999 Nov (revised 2011 Dec 21). NGC:008846. http:// www.guideline.gov/content.aspx?id=35123.
  16. Fedorowicz Z., Jagannath V.A., Carter В. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents. Cochrane Database Syst Rev. 2011;7:005506.
  17. Levine D. Oral ondansetron decreases vomiting, as well as the need for intravenous fluids and hospital admission, in children with acute gastroenteritis. Evid. Based Med. 2012;17():112-13.
  18. Carter B., Fedorowicz Z. Antiemetic treatment for acute gastroenteritis in children: an updated Cochrane systematic review with metaanalysis and mixed treatment comparison in a Bayesian framework. BMJ. Open. 2012;2:000622.
  19. Freedman S.B., et al. Oral ondansetron for gastroenteritis in a pediatric emergency department. N. Engl. J. Med. 2006;354(16):1698705.
  20. Freedman S.B., Pasichnyk D., Black K.J., Fitzpatrick E., Gouin S., Milne A., Hartling L. Pediatric Emergency Research Canada Gastroenteritis Study Group, Gastroenteritis Therapies in Developed Countries: Systematic Review and Meta-Analysis. PLoS One. 2015;10(6).
  21. Leung A.K., Robson W.L. Acute gastroenteritis in children: role of anti-emetic medication for gastroenteritis-related vomiting. Paediatr. Drugs. 2007;9(3):17584.
  22. Халиуллина С.В., Анохин В.А. Терапия острых кишечных инфекций у детей. Доказанная эффективность (Обзор литературы). Журнал инфектологии. 2013;5(4):5-13.
  23. Куличенко Т.В., Бакрадзе М.Д., Патрушева Ю.С. Острая инфекционная диарея у детей. Педиатр. фармакол. 2009;6(3):97-103.
  24. Alhashimi D., Alhashimi H., Fedorowicz Z. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents. Cochrane Database Syst. Rev. 2006;18:005506.
  25. Mehra K., Gogtay N.J., Ainchwar R., Bichile L.S. Hypersensitivity to intravenous ondansetron: a case report. J. Med. Case Reports. 2008;2:274.
  26. Szajewska H., Gieruszczak-Bialek D., Dylag M. Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children. Aliment Pharmacol. Ther. 2007;25(4):93-400.
  27. Evidence-based care guideline for prevention and management of acute gastroenteritis (AGE) in children aged 2 months to 18 years. 1999 Nov (revised 2011 Dec 21). NGC:008846. - http://www.guideline.gov/content. aspx?id=35123&search.
  28. Leung A.K., Robson W.L. Acute gastroenteritis in children; role of anti-emetic medication for gastroenteritis-related vomiting. Pediatr. Drugs. 2007;9:175-84.
  29. Li S.T., DiGiuseppe D., Christakis D.A. Antiemetic use for acute gastroenteritis in children. Arch. Pediatr. Adolesc. Med. 2003;157 475-79.
  30. DeCamp L.R., Byerley J.S., Doshi N., Michael J. Use of antiemetic agents in acute gastroenteritis. Arch. Pediatr. Adolesc. Med. 2008; 162(9):858-65.
  31. Cheng A. Emergency department use of oral ondansetron for acute gastroenteritis-related vomiting in infants and children; Canadian Paediatric Society Acute Care Committee Paediatr. Child. Health. 2011;16(3):177-79.
  32. Reeves J.J., Shannon M.W., Fleisher G.R. Ondansetron decreases vomiting associated with acute gastroenteritis: a randomized, controlled trial. Pediatrics. 2002;109(4):e62.
  33. Guarino A., Ashkenazi S., Gendrel D., Lo Vecchio A., Shamir R., Szajewska H. «European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases Evidence-Based Guidelines for the Management of Acute Gastroenteritis in Children in Europe: Update 2014». J. Pediatr. Gastroenterol. Nutr. 2014;59:132-52.
  34. «Оказание стационарной помощи детям, Руководство по ведению наиболее распространенных болезней детского возраста», 2-е издание, ВОЗ, 2013. С. 123-44.

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