POTENTIALS FOR THE USE OF URSODEOXYCHOLIC ACID IN THE THERAPY OF INTRAHEPATIC CHOLESTASIS OF PREGNANCY


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Abstract

According to modern concepts, intrahepatic cholestasis of pregnancy (IHCP) is a cholestatic liver disease that develops in II and III trimesters of pregnancy, and characterized by itching and increased concentration of bile acids in the blood serum. Currently, ursodeoxycholic acid is considered as the drug of choice for the treatment of IHCP as defined by substantial evidence of efficacy and safety of the drug within the treatment of this pathology.

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About the authors

Yu. S Gulenchenko

FBHCISCH MIA of Russia

E. V Partsvania-Vinogradova

Branch Branch SBHCI CP №115 MHCD CP № 79; SBEI HPE "Moscow State Medical Stomatological University n.a. A.I. Evdokimov" of RMH

Email: katrin3108@mail.ru
therapists at the Branch; resident physician at the Department of Propedeutics of Internal Diseases and Gastroenterology

D. T Dicheva

SBEI HPE "Moscow State Medical Stomatological University n.a. A.I. Evdokimov" of RMH

D. N Andreev

SBEI HPE "Moscow State Medical Stomatological University n.a. A.I. Evdokimov" of RMH

A. V Zaborovskiy

SBEI HPE "Moscow State Medical Stomatological University n.a. A.I. Evdokimov" of RMH

L. A Tararina

SBEI HPE "Moscow State Medical Stomatological University n.a. A.I. Evdokimov" of RMH

References

  1. Маев И.В., Андреев Д.Н., Дичева Д.Т., Казначеева Т.В. Внутрипеченочный холестаз беременных: современное состояние проблемы. Клин. мед. 2015; 6: 25-30.
  2. Bacq Y. Intrahepatic cholestasis of pregnancy. Clin. Liver. Dis. 1999; 3: 1.
  3. Pan C., Perumalswami P.V. Pregnancy-related liver diseases. Clin. Liver. Dis. 2011; 15(1): 199-208.
  4. Arrese M., Macias R.I., Briz O., Perez M.J., Marin J.J. Molecular pathogenesis of intrahepatic cholestasis of pregnancy. Expert. Rev. Mol. Med. 2008; 10: e9.
  5. Bacq Y., Gendrot C., Perrotin F., Lefrou L., Chretien S., Vie-Buret V., Brechot M.C., Andres C.R. ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahe-patic cholestasis of pregnancy. J. Med. Genet. 2009; 46: 711.
  6. Jacquemin E., Cresteil D., Manouvrier S., Boute O., Hadchouel M. Heterozygous non sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. Lancet. 1999; 353: 210.
  7. Van Mil S.W., Milona A., Dixon P.H., Mullenbach R., Geenes V.L., Chambers J., Shevchuk V., Moore G.E., Lammert F., Glantz A.G., Mattsson L.A., Whittaker J., Parker M.G., White R., Williamson C. Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. Gastroenterology 2007; 133: 507.
  8. Sookoian S., Castano G., Burgueno A., Gianotti T.F., Pirola C.J. Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy. J. Hepatol. 2008; 48: 125.
  9. Reyes H., Simon F.R. Intrahepatic cholestasis of pregnancy: an estrogen-related disease. Semin. Liver. Dis. 1993; 13: 289.
  10. Gonzalez M.C., Reyes H., Arrese M., Figueroa D., Lorca B., Andresen M., Segovia N., Molina C., Arce S. Intrahepatic cholestasis of pregnancy in twin pregnancies. J. Hepatol. 1989; 9: 84.
  11. Meng L.J., Reyes H., Palma J., Hernandez I., Ribalta J., Sjövall J. Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy. J. Hepatol. 1997; 27: 1029-40.
  12. Kenyon A.P., Piercy C.N., Girling J., Williamson C., Tribe R.M., Shennan A.H. Obstetric cholestasis, outcome with active management: a series of 70 cases. BJOG. 2002; 109: 282-88.
  13. Reyes H. Review: intrahepatic cholestasis. A puzzling disorder of pregnancy. J. Gastroenterol. Hepatol. 1997; 12(3): 211-16.
  14. Borum M.L. Hepatobiliary diseases in women. Med. Clin. North. Am. 1998; 82(1): 51-75.
  15. Knox T.A., Olans L.B. Liver disease in pregnancy. N. Engl. J. Med. 1996; 335(8): 569-76.
  16. Pusl T., Beuers U. Intrahepatic cholestasis of pregnancy. Orphanet. J. Rare. Dis. 2007; 2: 26.
  17. Heikkinen J., Maentausta O., Ylöstalo P., Janne O. Changes in serum bile acid concentrations during normal pregnancy, in patients with intrahepatic cholestasis of pregnancy and in pregnant women with itching. Br. J. Obstet. Gynaecol. 1981; 88: 240.
  18. Lunzer M., Barnes P., Byth K., O'Halloran M. Serum bile acid concentrations during pregnancy and their relationship to obstetric cholestasis. Gastroenterology. 1986; 91: 825.
  19. Brites D., Rodrigues C.M., Oliveira N., Cardoso M., Graca L.M. Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy. J. Hepatol. 1998; 28: 91-8.
  20. Hay J.E. Liver disease in pregnancy. Hepatology. 2008; 47(3): 1067-76.
  21. Palma J., Reyes H., Ribalta J., Hernandez I., Sandoval L., Almuna R., Liepins J., Lira F., Sedano M., Silva O., Toha D., Silva J.J. Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, doubleblind study controlled with placebo. J. Hepatol. 1997; 27: 1022.
  22. Rolfes D.B., Ishak K.G. Liver disease in pregnancy. Histopathology. 1986; 10: 555.
  23. Bacq Y., Sapey T., Brechot M.C., Pierre F., Fignon A., Dubois F. Intrahepatic cholestasis of pregnancy: a French prospective study. Hepatology. 1997; 26: 358.
  24. Ribalta J., Reyes H., Gonzalez M.C., et al. S-adenosyl-L-methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: a randomized, double-blind, placebo-controlled study with negative results. Hepatology. 1991; 13: 1084.
  25. Frezza M., Pozzato G.,Chiesa L.,Stramentinoli G., di Padova C. Reversal of intrahepatic cholestasis of pregnancy in women after high dose S-adenosyl-L-methionine administration. Hepatology. 1984; 4: 274-28.
  26. Roncaglia N., Locatelli A., Arreghini A., Assi F., Cameroni I., Pezzullo J.C., Ghidini A. A randomised controlled trial of ursodeoxycholic acid and S-adenosyl-l-methionine in the treatment of gestational cholestasis. BJOG. 2004; 111: 17.
  27. Hirvioja M.L., Tuimala R., Vuori J. The treatment of intrahepatic cholestasis of pregnancy by dexamethasone. Br. J. Obstet. Gynaecol. 1992; 99: 109.
  28. Glantz A., Marschall H.U., Lammert F., Mattsson L.A. Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid. Hepatology. 2005; 42: 1399.
  29. Bacq Y., Sentilhes L., Reyes H.B., Glantz A., Kondrackiene J., Binder T., Nicastri P.L., Locatelli A., Floreani A., Hernandez I., Di Martino V. Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a metaanalysis. Gastroenterology. 2012; 143: 1492-501.
  30. Zapata R., Sandoval L., Palma J., Hernandez I., Ribalta J., Reyes H., Sedano M., Toha D., Silva J.J. Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy. A 12-year experience. Liver. Int. 2005; 25: 548-54.

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