PRESSURIZED INTRAPERITONEAL AEROSOL CHEMOTHERAPY (PIAC) IN COMBINATION WITH SYSTEMIC CHEMOTHERAPY FOR STOMACH CANCER PATIENTS WITH PERITONEAL DISSEMINATION


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Peritoneal carcinomatosis (PC) in stomach cancer (SC) occurs in more than 50% of patients. The median survival of patients without treatment is 3-6 months, with systemic chemotherapy (SC) - rarely more than 8-12 months. The use of pressurized intraperitoneal aerosol chemotherapy (PIAC) allows to improve the results of treatment of this difficult group of patients. According to the protocol of the clinical study, all the patients at the first stage underwent staging laparoscopy or laparotomy, 3-4 courses of systemic chemotherapy followed by 3 sessions of PIAC with an interval of 6 weeks against the background of continuing systemic chemotherapy. In the case of progression, the patient was eliminated from the study. The main criteria for progression included: increase in peritoneal cancer index (PCI) > 50%, the development of distant nodal and hematogenous metastases, lack of medical pathomorphosis according to repeated biopsies or pronounced deterioration in the general condition. The study included 37 patients (11 men, 26 women, mean age - 53.4 years), among them 26 stomach cancer patients with synchronously diagnosed PC and 11 patients with metachronously diagnosed isolated PC after previous treatment. Middle PCI was 12.9 (3 to 34) points. Total of 68 PIAC procedures were performed. Objective pathomorphological response was obtained in 87.5% of cases, including complete response in 25% of patients. Median survival was 14 months, one-year survival rate - 47.8%. Thus, a combined approach to treatment of PC in SC combining systemic chemotherapy according to the XELOX scheme and PIAC with low doses of cisplatin and doxorubicin leads to an objective regression of the tumor and increases overall survival.

Толық мәтін

Рұқсат жабық

Авторлар туралы

A. Kaprin

MSROI n.a. P.A. Herzen - branch FSBI NMRRC of RMH Moscow

V. Khomyakov

Email: vladimirkhom@mail.ru
MSROI n.a. P.A. Herzen - branch FSBI NMRRC of RMH PhD, Head of Thoracoabdominal Department Moscow

A. Ryabov

MSROI n.a. P.A. Herzen - branch FSBI NMRRC of RMH Moscow

L. Bolotina

MSROI n.a. P.A. Herzen - branch FSBI NMRRC of RMH Moscow

A. Ivanov

MSROI n.a. P.A. Herzen - branch FSBI NMRRC of RMH Moscow

A. Utkina

MSROI n.a. P.A. Herzen - branch FSBI NMRRC of RMH Moscow

N. Volchenko

MSROI n.a. P.A. Herzen - branch FSBI NMRRC of RMH Moscow

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