RATIONALE FOR USE OF ALFACALCIDOL IN COMBINATION WITH BISPHOSPHONATES IN POSTMENOPAUSAL AND SENILE FORMS OF SYSTEMIC OSTEOPOROSIS


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Abstract

Assessment of the dynamics of bone mineral density (BMD) and parameters of calcium homeostasis in 163 patients with postmenopausal and senile forms of systemic osteoporosis treated with alfacalcidol in combination with bisphosphonates (112 patients received zoledronic acid, 51 - ibandronic acid) and calcium carbonate (1000-1200 mg/day), for 1 year confirmed that alfacalcidol, being a synthetic analogue of D-hormone, has a positive impact at personalized doses on most of the processes, which are negatively changed using bisphosphonates. In particular, the preservation of normal parameters of calcium homeostasis is a guarantee of BMD increase in this case.

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S. S Rodionova

Email: rod06@inbox.ru
MD, Prof., Head of Scientific and Clinical Center of Osteoporosis FSBI «Central Scientific Research Institute of Traumatology and Orthopedics n.a. N.N. Priorov» of RMH Moscow

U. R Khakimov

Clinical Research Center of Osteoporosis FSBI CITO n.a. N.N. Priorov of RMH Moscow

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