No 3S (2016)

The article is devoted to a relevant topic - the relationship of calcium and bone metabolism under normal and pathological conditions. The complexity and correlation of these processes is shown. The cellular and molecular characteristics of calcium metabolism in the serum and bone tissue are discussed in detail. The article presents the modern views on the primary, secondary and contributing factors influencing the calcium metabolism. Physiological role of calcium in the human body in general and particularly in bone metabolism is clarified. The characteristic features of bone metabolism from the perspective of of cell pool, morphological types of bone tissue and their functional consistency are considered. The clinical significance of hypercalcemia is emphasized in view of the emergence of new cancer markers and subclinical inflammation markers. The role of calcium supplements in the treatment of osteoporosis from the standpoint of evidence-based medicine recommendations is discussed.

Despite the fact that there are many drugs with different mechanisms of action for the pain relief in osteoarthritis, none of them have an absolute efficiency. Along with well-known traditional methods of treatment of OA, which are usually used in accordance with national clinical guidelines and protocols of management of patients, there are alternative methods. Phytotherapy is one of such methods, which is widely used in various joint diseases. Currently, the multicomponent drugs known as Zeel T and Traumeel S, are manufactured for practical application in different forms.

Anti-neutrophil cytoplasmic antibody-associated systemic vasculitides (ANCA-SV) are characterized by multiple organ lesions, clinical and immunological heterogeneity of types, a variety of manifestations, and at all stages of disease require a quality interaction between patient and doctor. The basis for successful therapy is a rational and personalized maintenance of delicate balance between the use of evidence-based treatment protocol sufficient to suppress the persistent activity of ANCA-SV, and, at the same time, control the risk of treatment complications. In response to the growing need for improved approaches to the management of patients with ANCA-SV, specialists at the FSBEI SRIR n.a. V.A. Nasonova have developed a National register of patients with ANCA-SV, which is regularly updated electronic database of dynamic monitoring of patients; it should be considered as an innovative tool for personalized induction and maintenance therapy, corresponding to the modern "treat to target“ concept. The main task of register is a stable reproduction of ANCA-SV treatment goals, including maintaining stable remission, reducing the risk of adverse effects of treatment, control of comorbid disease, and achievement of high quality of life. Further development of the National Register of ANCA-SV patients as the federal program can play a key role in improving the treatment of patients with rare and serious diseases, contribute to the development of informational and telecommunicational medical technologies to provide opportunities for emergency counseling and medical assistance in expert centers to patients with ANCA-SV, succession at different stages of treatment, reduction of pharmaco-economic costs.