FEATURES OF DEVELOPMENT OF NEUROENDOCRINE DYSFUNCTION IN PATIENTS WITH SCHIZOPHRENIA IN OUTPATIENT PRACTICE (NATURALISTIC STUDY)
- Authors: Gorobets L.N1, Bulanov V.S1, Litvinov A.V1
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Affiliations:
- Moscow SRI of Psychiatry - Branch of FSBI FMRCPN n.a. V.P. Serbsky of RMH
- Issue: No 4S (2016)
- Pages: 41-45
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289725
- ID: 289725
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Abstract
The article discusses data on the frequency of incidence of neuroendocrine dysfunction (NED) in patients with paranoid schizophrenia during long-term antipsychotic therapy in outpatient practice in the comparative aspect. Generally, NED has formed in 94.3% of patients. Frequency of development of NED in patients varied from 90.5 to 100% depending on therapy options. NED in patients with paranoid schizophrenia with appointment of two or more antipsychotics or combination of antidepressant and antipsychotic compared with first and second generation antipsychotics used as monotherapy are formed significantly more often (p<0.01). Average prolactin levels were significantly higher (p<0.01) in women with all variants of therapy and significantly higher (p<0.01) than those against the background of treatment with second-generation antipsychotics, regardless of gender. In addition, the spectrum of clinical manifestations of syndrome of neuroleptic-induced hyperprolactinemia in women was significantly greater compared to male patients.
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About the authors
L. N Gorobets
Moscow SRI of Psychiatry - Branch of FSBI FMRCPN n.a. V.P. Serbsky of RMH
Email: gorobetsln@mail.ru
MD, Prof., Head of the Department of Psychiatric Endocrinology Moscow
V. S Bulanov
Moscow SRI of Psychiatry - Branch of FSBI FMRCPN n.a. V.P. Serbsky of RMHMoscow
A. V Litvinov
Moscow SRI of Psychiatry - Branch of FSBI FMRCPN n.a. V.P. Serbsky of RMHMoscow
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