Possibilities of metabiotic therapy in the correction of gastrointestinal symptoms and violations of intestinal microbiota in patients with lung cancer during chemotherapy
- Authors: Serkova M.Y.1, Avalueva E.B1, Orlov S.V2
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Affiliations:
- FSBEI HE “North-Western State Medical University n.a. I.I. Mechnikov" of RMH
- FSBEI HE “First Saint-Petersburg State Medical University n.a. Academician I.P. Pavlov" of RMH
- Issue: No 5S (2016)
- Pages: 55-59
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289738
- ID: 289738
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Abstract
The article presents data on the dynamics of gastrointestinal symptoms and changes in gastrointestinal microbiocenosis in patients with a diagnosis of «lung cancer», receiving chemotherapy, and influence of metabiotic drug appointed in addition to the basic treatment regimens on these parameters. The study included 41 patients who received the first cycle of first-line chemotherapy for lung cancer (mean age - 61.7±6.4 years, mean duration of disease - 12.3±8.5 months). The patients were divided into 2 groups: treatment group (n=21) received a course of metabiotic drug on the basis of the lyophilized strain of Bacillus subtilis and natural zeolite 2 capsules 2 times a day with meals for 28 days in addition to the chemotherapy; the control group (n=20) received only chemotherapeutic agents. Standardized survey of each patient to detect gastrointestinal complaints, assessment the quality of life (GSRS questionnaire), microbiological examination of faeces, and the evaluation of microorganisms metabolites in blood using gas-liquid chromatography - mass spectrometry according to the method of G.A. Osipov, were performed at the 1st and 29th day from the start of chemotherapy. Patients with a diagnosis of lung cancer on the background of the toxic effect of chemotherapy had the confirmed progression of gastrointestinal complaints and changes in qualitative and quantitative composition of intestinal microflora: a significant reduction in the number of bifidobacteria and Bacteroides, to a lesser extent - lactobacilli, increased activity of pathogenic intestinal microflora: Peptostreptococcus anaerobius, Pseudomonas aeruginosa, Fusobacterium/Haemophylus, Clostridium rerfrin-gens, Moraxella/Acinetobacter, Bacteroides fragilis. Additional metabiotic treatment allows to keep the original number of obligate intestinal microorganisms and reduce the phenomenon of intestinal dyspepsia in patients diagnosed with lung cancer receiving chemotherapy.
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About the authors
M. Yu Serkova
FSBEI HE “North-Western State Medical University n.a. I.I. Mechnikov" of RMH
Email: serkova.margarita@yandex.ru
Teaching Assistant at the Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietology
E. B Avalueva
FSBEI HE “North-Western State Medical University n.a. I.I. Mechnikov" of RMHDepartment of Propaedeutics of Internal Diseases, Gastroenterology and Dietology
S. V Orlov
FSBEI HE “First Saint-Petersburg State Medical University n.a. Academician I.P. Pavlov" of RMH
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