Development of functional pancreatic insufficiency after resection surgery and ways for its correction
- Authors: Dubtsova E.A1, Nikolskaya K.A1, Vinokourova L.V1, Bordin D.S1, Varvanina G.G1, Agafonov M.A1
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Affiliations:
- SBHCIMCSPC of Moscow Healthcare Department
- Issue: No 2 (2017)
- Pages: 39-42
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289763
- ID: 289763
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Abstract
The article provides an analysis of the results of evaluation of 87 patients who underwent resection surgery for various diseases of the pancreas. The severity of functional pancreatic insufficiency was assessed. The study has shown that pancreatoduodenal resection led to predominantly severe exocrine insufficiency, and distal resection - to moderate exocrine insufficiency. Diabetes mellitus after surgery occurred in 13.3% of patients who underwent pancreatoduodenal resection, and 100% of patients required correction of functional pancreatic insufficiency with high doses of enzymes and insulin preparations after pancreatectomy. The results showed that all patients who have undergone resection of the pancreas need constant enzyme replacement therapy and control of glycemia to a greater or lesser extent.
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About the authors
E. A Dubtsova
SBHCIMCSPC of Moscow Healthcare Department
Email: e.dubtsova@mknc.ru
MD, Head of the Department of Pathology of the Pancreas and Biliary Tract
K. A Nikolskaya
SBHCIMCSPC of Moscow Healthcare Department
L. V Vinokourova
SBHCIMCSPC of Moscow Healthcare Department
D. S Bordin
SBHCIMCSPC of Moscow Healthcare Department
G. G Varvanina
SBHCIMCSPC of Moscow Healthcare Department
M. A Agafonov
SBHCIMCSPC of Moscow Healthcare Department
References
- Коротько Г.Ф. Постпрандиальная секреция поджелудочной железы. Краснодар, 2017. 132 с.
- Лебедев Н.Н. Биоритмы пищеварительной системы. М., 1987. 256 с.
- Metzger A., Di Magno E.P. Enzymes and Digestion. The Pancreas. Eds. H.G. Beger, et al. Blackwell Science. 1998;1:147-60.
- Губергриц Н.Б., Беляева Н.В. Новости мировой панкреатологии (по материалам совместной встречи Международной ассоциации панкреатологов и Корейской панкреатобилиарной ассоциации, Южная Корея, Сеул. 04-07.09.2013). Вестник клуба панкреатологов. 2014;2(22):4-9.
- Губергриц Н.Б., Казюлин А.Н. Метаболическая панкреатология. Донецк, 2011. 460 с.
- Tiengo A., Vigili de Kreutzenberg S., Del Prato S. Diabetes in pancreatitis, pancreatectomy and other pancreatic diseases. (Eds E. Ghido, M. Porta): Diabetes Secondary to Endocrine and Pancreatic Disorders Front Diabetes. Basel/ Karger. 2014;22:119-43.
- Burkhart R.A., Gerber S.M., Tholcy R.M., Lamb R.V., et. al. Incidence and severity of pancreatogenic diabetes after pancreatic resection. J. Gastrointest Surg. 2014. Published on-line: 15 October 2014. DOI 10/1007/s11605-014-2669-z.
- Waljee A.K., DiMagno M.J., Wu B.U., Schoenfeld P.S., Conwell D.L. Systematic review: pancreatic enzyme treatment of malabsorption associated with chronic pancreatitis. Aliment. Pharmacol. Ther. 2009;29:235e46.
- Taylor J.R., Gardner T.B., Waljee A.K., DiMagno M.J., Schoenfeld P.S. Systematic. review: efficacy and safety of pancreatic enzyme supplements for exocrine.pancreatic insufficiency. Aliment. Pharmacol. Ther. 2010;31:57e72.
- Dominguez-Munoz J.E., Iglesias-Garcia J. Oral pancreatic enzyme substitution therapy in chronic pancreatitis: is clinical response an appropriate marker for evaluation of therapeutic efficacy? JOP 2010;11:158e62.
- Andersen D.K. The practical importance of recognizing pancreatogenic or type 3c diabetes. Diabetes Metab. Res. Rev. 2012;28:26-328.
- Scavini M., Dugnani E., Pasquale V., Liberati D., Aleotti F., Di Terlizzi G., Petrella G., Bakmzano G. Diabetes after pancreatic surgery: novel issues. Curr. Diab. Rep. 2015;15:16. Published on-line: 22 February 2015.
- American Diabetes Assocition. Diagnosis and classification of diabetes mellitus. Liabttes Care. 2012;35:64-S71.
- Martinez A., Abad-González J.R., Aparicio L., Aparisi J., Boadas E., Boix G., de las Heras E., Dominguez-Muñoz A., Farré L., Fernández-Cruz L., Gómez J., Iglesias-García K., García-Malpartida L., Guarner J., Lariño-Noia F. Liuis A., Lópezm X., Molero O., Moreno-Pérez S., Navarro J.M., Palazón M., Pérez-Mateo L., Sabater Y., Sastre E., Vaquero E., de-Madaria. The Spanish Pancreatic Club recommendations for the diagnosis and treatment of chronic pancreatitis: Part 2 (treatment) Pancreatology. 2013;13:18-28.
- Ребров А.П., Куницына М.А., Кашкина Е.И., Архангельская Е.Е. Панкреатогенный сахарный диабет: актуальная проблема патогенеза и лечения (обзор). Саратовский научно-медицинский журн. 2012;8(3):862-67.
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