PLASMA HAEMOSTASIS AND GASTRODUODENAL MUCOSAL BLOOD FLOW IN PATIENTS WITH GASTRODUODENAL ULCER DISEASE WITH HISTORY OF BLEEDING


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The problem of hemorrhagic complications of duodenal ulcer disease (DUD) remains relevant. The DUD patients with history of blee-ding were different from those with uncomplicated disease by age and gender characteristics, as well as hypercoagulable changes in blood plasma that correlated with the frequency and duration of hemorrhagic episodes. In patients with uncomplicated DUD and DUD with a history of bleeding, no differences in the histological and microhemocirculatory parameters of the gastroduodenal mucosa were observed. Secondary prophylaxis of hemorrhagic complications in DUD should include not only control of the infection of Helicobacter pylori, the use of non-steroidal anti-inflammatory drugs and concomitant pathology, but also mandatory monitoring and correction of plasma hemostasis.

Full Text

Restricted Access

About the authors

V. V Gorban

FSBEI HE “Kuban State Medical University" of RMH

Email: gorbanvv@mail.ru
MD, Head of the Department of Polyclinic Therapy with the course of GP (FM) FATPRS

L. V Burba

FSBEI HE “Kuban State Medical University" of RMH

References

  1. Sung J.J., Kuipers E.J., El-Serag H.B. Systematic review: the global incidence and prevalence of peptic ulcer disease. Aliment. Pharmacol. Ther. 2009;29(9):938-46.
  2. Huang T.C., Lee C.L. Diagnosis, Treatment, and Outcome in Patients with Bleeding Peptic Ulcers and Helicobacter pylori Infections. BioMed. Res. Int. 2014;2014:658108.
  3. Гастроэнтерология. Национальное руководство краткое издание / Под ред. В.Т. Ивашкина, Т.Л. Лапиной. М., 2011.
  4. Маев И.В., Гончаренко А.Ю., Дичева Д.Т., Андреев Д.Н., и др. Лечение язвенных кровотечений и профилактика их рецидивов: взгляд терапевта. Медицинский совет. 2013;10:22-6.
  5. Маев И.В., Стрючкова Е.Ю., Фомин В.С., Стручков В.Ю., Бархатова И.В. и др. Мультидисциплинарный подход к лечению гастродуоденальных кровотечений. Фарматека. 2016;15:68-72.
  6. Holster I.L., Kuipers E.J. Management of acute nonvariceal upper gastrointestinal bleeding: current policies and future perspectives. World J. Gastroenterol. 2012;18(11):1202-207.
  7. Van Leerdam M.E. Epidemiology of acute upper gastrointestinal bleeding. Best Pract. Res. Clin. Gastroenterol. 2008;22(2):209-24.
  8. Malfertheiner P., Megraud F., O'Morain C., Bazzoli F., El-Omar E., Graham D., Hunt R., Rokkas T., Vakil N., Kuipers E.J. Current conceptson the management of Helicobacter Pylori infection: the Maastricht III Consensus Report. Gut. 2007;56(6):772-81.
  9. Barkun A.N., Bardou M., Kuipers E.J., Sung J., Hunt R.H., Martel M., Sinclair P; International Consensus Upper Gastrointestinal Bleeding Conference Group. International consensus on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann. Intern. Med. 2010;152(2):101-13.
  10. Van Leerdam M.E., Tytgat G.N.J. Review article: Helicobacter pylori infection in peptic ulcer haemorrhage. Aliment. Pharmacol. Ther. 2002;16 (suppl.1):66-78.
  11. Hsu P.I. New look at antiplatelet agent-related peptic ulcer: an update of prevention and treatment. J. Gastroenterol. Hepatol. 2012;27(40):654-61.
  12. Laine L., Jensen D.M. Management of patients with ulcer bleeding. Am. J. Gastroenterol. 2012;107:345-60.
  13. Чарная М.А., Морозов Ю.А., Гладышева В.Г. Использование метода тромбоэластографии для диагностики и выбора тактики коррекции нарушений системы гемостаза в кардиохирургической клинике. Вестник анестезиологии и реаниматологии. 2010; 1:28-33.
  14. Chitlur M., Sorensen B., Rivard G.E., Young G., ngerslev J., Othman M., Nugent D., Kenet G., Escobar M., Lusher J. Standardization of thromboelastography: a report from the TEG-ROTEM working group. Haemophilia. 2011;17(3):532-37.
  15. Маев И.В., Горбань В.В., Салова Л.М. Кровоток и морфо-функциональное состояние гастродуоденальной слизистой в разные фазы язвенной болезни. Тер. архив. 2007;79(8):57-62.
  16. Chung W.C., Jeon E.J., Kim D.B., Sung H.J., Kim Y.J., Lim E.S., Kim M.A., Oh J.H. Clinical characteristics of Helicobacter pylori - negative drug negative peptic ulcer bleeding. World J. Gastroenterol. 2015;21(28):8636-43.
  17. Чернин В.В., Миллер Д.А., Соловьев В.А. Хронический гастрит в аспекте тромбогеморрагического синдрома. Тверь, 2005.
  18. Barinov E., Sulaieva O., Lyakch Y., Guryanov V., Kondratenko P., Radenko Y. Platelet aggregation measurement for assessment of hemostasis failure mechanisms in patients with gastroduodenal ulcer bleeding. Clin. Exp. Gastroenterol. 2013;6:139-48.
  19. Jackson C.S., Gerson L.B. Management of gastrointestinal angiodysplastic lesions (GIADs): a systematic review and meta-analysis. Am. J. Gastroenterol. 2014;109:474-83.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies