Opportunities of combined targeted therapy with vemurafenib and cobi-metinib in metastatic BRAF-positive cutaneous melanoma: long-term results of clinical trials
- 作者: Orlova K.V1, Demidov L.V1
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隶属关系:
- FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH
- 期: 编号 17 (2017)
- 页面: 55-61
- 栏目: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/290003
- ID: 290003
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详细
This article discusses in detail the possibilities of combined therapy with vemurafenib+cobimetinib (V+C) in patients with metastatic skin melanoma. In the coBRIM study, about 50% of patients in the group of combination therapy V+C had an unfavorable prognosis factor - an elevated lactate dehydrogenase (LDH) level. Despite this, the median progression-free survival and median overall survival rates were high, which points out the possibility of the use of combined targeted V+C therapy in patients with elevated LDH levels. The article also discusses the results of the BRIM7 study, which are of great interest due to the presence of a group of patients previously treated with BRAF inhibitors.
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作者简介
K. Orlova
FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH
Email: krisman03@gmail.com
PhD, Senior Clinical Researcher at the Department of Biotherapy
L. Demidov
FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH
参考
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