Opportunities of combined targeted therapy with vemurafenib and cobi-metinib in metastatic BRAF-positive cutaneous melanoma: long-term results of clinical trials


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Resumo

This article discusses in detail the possibilities of combined therapy with vemurafenib+cobimetinib (V+C) in patients with metastatic skin melanoma. In the coBRIM study, about 50% of patients in the group of combination therapy V+C had an unfavorable prognosis factor - an elevated lactate dehydrogenase (LDH) level. Despite this, the median progression-free survival and median overall survival rates were high, which points out the possibility of the use of combined targeted V+C therapy in patients with elevated LDH levels. The article also discusses the results of the BRIM7 study, which are of great interest due to the presence of a group of patients previously treated with BRAF inhibitors.

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Sobre autores

K. Orlova

FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH

Email: krisman03@gmail.com
PhD, Senior Clinical Researcher at the Department of Biotherapy

L. Demidov

FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH

Bibliografia

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