Visual disturbances and Alzheimer’s disease


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Abstract

This article presents an analytical overview of possible prospects for the diagnosis of Alzheimer’s disease (AD) using optical coherence tomography. The urgency of this problem is determined by the steady increase in the number of patients suffering from dementia, in whom 60-80% of cases of dementia are caused by AD. Data on the structural and functional changes in the visual analyzer in AD are discussed. The problem of preclinical diagnosis of AD using optical coherence tomography (OCT) is considered as an actual problem. OCT is a non-invasive method of intravital examination, allowing to obtain a cross-sectional image of the tissue. The available literature data interpret the parameters of the retinal OCT imaging as a potential biomarker of the early stage of AD.

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About the authors

A. N Bogolepova

FSBEI HE RNSMU n.a. N.I. Pirogov of RMH

Email: annabogolepova@yandex.ru
MD, Prof. at the Department of Neurology, Neurosurgery and Medical Genetics of the Medical Faculty

E. V Makhnovich

FSBEI HE RNSMU n.a. N.I. Pirogov of RMH

A. N Zhuravleva

FSBEI “Moscow Scientific Research Institute of Eye Diseases n.a. Helmholtz" of RMH

T. A Donskikh

SBHCI “City Polyclinic № 212" of Moscow Healthcare Department

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