Pseudomembranous colitis: risk factors, clinical picture, treatment

  • Авторлар: Potapova T.V1,2, Ermolenko K.D3,4, Lioznov D.A1
  • Мекемелер:
    1. First St. Petersburg State Medical University n.a. I.P. Pavlov
    2. Clinical Infectious Diseases Hospital n.a. S.P. Botkin
    3. Children's Scientific and Clinical Center of Infectious Diseases of the Federal Medical Biological Agency
    4. SRI of Epidemiology and Microbiology n.a. Pasteur
  • Шығарылым: № 2 (2018)
  • Беттер: 64-68
  • Бөлім: Articles
  • URL: https://journals.eco-vector.com/2073-4034/article/view/294576
  • ID: 294576

Дәйексөз келтіру

Толық мәтін

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Аннотация

Purpose of the study. Analysis of modern aspects of the clinical and laboratory course of pseudomembranous colitis (PMC), and the determination of the optimal treatment regimens for this disease. Material and Methods. Using continuous sampling method, 122 patients with PMC aged 18 to 96 years, including 35 (28.7%) men and 87 (71.3%) women, were enrolled in study. Results. During an endoscopic examination, a typical macroscopic picture was revealed in all patients: whitish-yellowish pseudomembranous plaques were found throughout the distal sections of the mucous membrane of the colon. Development of PMC was most often preceded by courses of antibacterial drugs from groups of fluoroquinolones and cephalosporins. As etiotropic drugs in the complex therapy of PMC, metronidazole and vancomycin were used. Conclusions. PMC is a variant of the severe course of antibiotic-associated diarrhea (AAD). For effective treatment of PMC, complex therapy is needed, including etiotropic agents, probiotic drugs and pathogenetic agents. Colonoscopy in patients with AAD can significantly increase the frequency of detection of severe forms of this condition and timely adjust the drug therapy.

Толық мәтін

Рұқсат жабық

Авторлар туралы

T. Potapova

First St. Petersburg State Medical University n.a. I.P. Pavlov; Clinical Infectious Diseases Hospital n.a. S.P. Botkin

K. Ermolenko

Children's Scientific and Clinical Center of Infectious Diseases of the Federal Medical Biological Agency; SRI of Epidemiology and Microbiology n.a. Pasteur

Email: ermolenko.kd@yandex.ru
Postgraduate Student; Researcher at the Department of Pathogen Identification

D. Lioznov

First St. Petersburg State Medical University n.a. I.P. Pavlov

Әдебиет тізімі

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