INTERCELLULAR ADHESION MOLECULES (E-CADHERIN, ß-CATENIN) IN COLORECTAL CANCER: CHARACTERISTICS; ROLE IN MECHANISMS OF TUMOR INVASION, METASTASIS AND REGULATION OF TUMOR PROGRESSION; INFLUENCE ON PROGNOSIS (LITERATURE REVIEW)


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Abstract

This review of the literature is devoted to the clinical significance of intercellular adhesion molecules (e-cadherin, ß-catenin) in colorectal cancer (CRC). Their detailed characteristic is given, the role in mechanisms of tumor invasion, metastasis and regulation of tumor progression is considered, their prognostic value is estimated. Intercellular adhesion molecules play an important role in the development of the invasive-metastatic potential of CRC. E-cadherin is a protein that belongs to the homologous transmembrane Ca2+-dependent glycoprotein family and provides intercellular adhesion in epithelial tissues. Beta-catenin is an intercellular multifunctional protein interacting directly with cadherins and indirectly with the actin cytoskeleton of cells. The clinical significance of the cadherin-catenin system of intercellular interactions in CRC is associated with an increase in the invasive-metastatic potential of tumors with abnormal expression of any of the components of this complex. This is due to the prognostic significance of different models of expression of the markers in colon adenocarcinomas and their metastases. In recent years, more and more data on the disturbances in the normal expression of intercellular adhesion molecules in CRC have accumulated, but their effect on the disease prognosis has not been adequately studied

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About the authors

A. D Darenskay

N.N. Blokhin National Medical Research Center of Oncology

Email: darenskaya@bk.ru
PhD, Junior Researcher at the Department of Chemotherapy and Combined Treatment of Malignant Tumors SRI of Clinical Oncology Moscow, Russia

N. V Dobrova

N.N. Blokhin National Medical Research Center of Oncology

Moscow, Russia

E. V Stepanova

N.N. Blokhin National Medical Research Center of Oncology

Moscow, Russia

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