Clinical features of axonal-demelinizing diabetic polyneuropathy
- Authors: Kovrazhkina E.A.1
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Affiliations:
- Research Institute of Cerebrovascular Pathology and Stroke, N.I. Pirogov Russian National Research Medical University
- Issue: No 11 (2018)
- Pages: 85-89
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/295751
- DOI: https://doi.org/10.18565/pharmateca.2018.11.85-88
- ID: 295751
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Abstract
Objective: to compare the clinical features of axonal and axonal-demyelinating distal symmetric diabetic polyneuropathy (DPN). Methods. Observational cohort study. The pathogenetic variant of DPN was diagnosed using electroneuromyography; based on its results, all patients were divided into 2 groups of 26 people each - with axonal and axonal-demyelinating polyneuropathy. The somatic and neurological status of the patients was examined; the severity of DPN was assessed on the basis of neurological symptom score (NSS, for subjective symptoms) and neuropathy disability score (NDS, for objective symptoms). Results. A total of 52 patients with DPN were examined. The group of patients with axonal-demyelinating variant of polyneuropathy demonstrated statistically significant differences with the group of axonal DPN: a high incidence of decompensation of diabetes mellitus (61.5 and 15.4% of patients, respectively, p<0.04), a higher NSS score (5,5±2.4 and 3.6±2.3, respectively, p<0.04) and NDS score (17.7±8.4 and 8.5±7.0, respectively, p<0.005), a greater frequency of additional symptoms of polyneuropathy (paresis, ataxia, muscular atrophy, 69.2 and 23.1% of patients, respectively, p<0.04). Conclusion. The axonal-demyelinating variant of DPN is associated with a more severe course of diabetes mellitus and a greater severity of polyneuropathy.
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About the authors
Elena A. Kovrazhkina
Research Institute of Cerebrovascular Pathology and Stroke, N.I. Pirogov Russian National Research Medical University
Email: elekov2@yandex.ru
Senior Scientist
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