Application of 0.1% methylprednisolone aceponate in the therapy of atopic dermatitis in children of the first year of life
- Authors: Khamaganova I.V1
-
Affiliations:
- Russian National Research Medical University n.a. N.I. Pirogov
- Issue: No 1S (2018)
- Pages: 40-43
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/296514
- ID: 296514
Cite item
Open Access
Access granted
Abstract
The article presents modern ideas about the skin features of children of the first year of life, and discusses factors that increase the risk of atopic dermatitis (AD). Objective: to evaluate the effectiveness and safety of the use of the methylprednisolone aceponate emulsion for children of the first year of life suffering from AD. Methods. The emulsion was applied to the inflammation sites of 26 patients of the first year of life who suffered from AD. There were 14 boys and 12 girls aged 4 to 12 months. All patients had erythematous-squamous foci of lesions on the cheeks with elements of exudation, 18 patients had lesions to the skin of the extremities and the buttocks, and the appearance of scaly crusts on the scalp was note in 6 patients. Results. The results obtained confirm the previously described high therapeutic efficacy and safety of topical therapy using the methylprednisolone aceponate emulsion for children of the first year of life. The course of treatment contributed to the rapid regress of the inflammatory phenomena, the restoration of night sleep, the elimination of itching and anxiety. There were no side effects. Conclusion. The efficacy and safety of topical application of 0.1% methylprednisolone aceponate in children of the first year of life, including on vulnerable areas of the skin, has been demonstrated.
Full Text
About the authors
I. V Khamaganova
Russian National Research Medical University n.a. N.I. Pirogov
Email: irina.khamaganova@gmail.com
MD, Prof. at the Department of Skin Diseases and Cosmetology FFPE
References
- Клинические рекомендации «Атопический дерматит» РААКИ. М., 2016.36 с.
- Sidbury R., Khorsand K. Evolving Concepts in Atopic Dermatitis. Curr. Allergy Asthma Rep. 2017;7:42.
- Grey K.R., Hook K.P., Polcari I.C., Maguiness S.M. Perceptions and Practices Regarding Atopic Dermatitis. Pediatr. Dermatol. 2017;34(4):488-91. doi: 10.1111/pde.13162.
- Andersen R.M., Thyssen J.P., Maibach H.l. Qualitative vs. quantitative atopic dermatitis criteria- in historical and present perspectives. J. Eur. Acad. Dermatol. Venereol. 2016;4:604-18.
- Hanifin J.M., Rajka G. Diagnostic features of atopic dermatitis. Acta. Derm. Venereol. 1980;92(Suppl.):44-7.
- Kikkawa T., Yorifuji T., Fuji Y., Yashiro M., Okada A., Ikeda M., Doi H., Tsukahara H. Birth Order and Pediatric Allergic Disease: A Nationwide Longitudinal Survey. Clin. Exp. Allergy. 2018 Jan 25. doi: 10.1111/cea.13100. [Epub ahead of print].
- Meylan P., Lang C., Mermoud S., Johannsen A., Norrenberg S., Hohl D., Vial Y., Prod'hom G., Greub G., Kypriotou M., Christen- Zaech S. Skin colonization by Staphulococcus aureus precedes the clinical diagnosis of atopic dermatitis in infancy. J. Invest. Dermatol. 2017;137(12):2497-504.
- Шливко И.Л., Каменский В.А., Донченко Е.В. Роль неинвазивных методов исследования в изучении структурных и функциональных особенностей кожи новорожденных. Рос. журн. кожных и венерических болезней.2013;5:30-7.
- Шарова Н.М. Бережный уход за кожей младенцев. Мед. совет2016;7:12-4.
- Torello A. Methylprednisolone aceponate for atopic dermatitis. Int. J. Dermatol. 2017; 6:691-97.
- Инструкция по применению препарата Адвантан в форме эмульсии от 11.05.2017, размещенная на сайте РЛС.
- Blume-Peytavi U., Wahn U. Optimizing the treatment of atopic dermatitis in children: a review of the benefit/risk ratio of methylprednisolone aceponate. J. Eur. Acad. Dermatol. Venerol. 2011;25:508-15.
- Machado S. Effective use of methylprednisolone aceponate 0,1 % in a 9- month old infant with atopic eczema and sleep disturbance. J. Eur. Acad. Dermatol. Venerol. 2012; 26(Suppl. 6):14-5.
- Torrelo A. Successful treatment of widespread eczema and sleep disruption in a 7- monthold infant with methylprednisolone aceponate 0,1%. J. Eur. Acad. Dermatol. Venerol. 2012; 26(Suppl. 6):16-7.
Supplementary files
