No 1S (2018)

The review is devoted to the analysis of the feasibility of assessing the content of serum and local cytokines in different phenotypes of allergic rhinitis, evaluating the diagnostic, prognostic and monitoring subcomponents of the cytokine profile parameters for various phenotypes of allergic rhinitis. The necessity of including a local cytokine profile in the diagnostic algorithm is emphasized.

The article considers the modern concepts of the etiology, pathogenesis and treatment of otitis externa. The authors discuss the most frequent causes of the development of diseases of the external ear, and the main nosological forms. The role of individual microorganisms in the genesis of the disease, the relationship of the type of pathogen, its biological properties and the nature of the course of inflammation are described in detail. The authors consider the possibilities of therapy of otitis externa taking into account the expected type of pathogen. The prospects for the use of topical therapy, the place of combined drugs in the treatment of acute and chronic diseases of the external ear are discussed. Authors'own clinical experience of the effective use of a combined preparation containing gentamycin, betamethasone and clotrimazole, in the form of ointment and cream is presented. The authors conclude that the topical therapy of otitis externa with combined preparation containing gentamycin, betamethasone and clotrimazole is possible.

Juvenile hemangiomas (JH) are the most common tumors of childhood, which, according to various researchers, occur in 3-12% of newborns. A new approach to the pharmacotherapy of JH is based on the effectiveness of the β-adrenergic blocker (β-AB timolol), and topical therapy of JH with β-AB appears the most relevant method of treatment of focal surface hemangiomas. Objective: to evaluate the properties of timolol in vitro, its clinical efficacy and safety in topical antiangiogenic therapy in children with superficial focal JH. Methods. Cytotoxicity, the effect of timolol on metabolism and active migration of cells in vitro (LDG test, WST test, cell migration and restoration of confluency of monolayer of cell culture) were evaluaeted. The clinical efficacy and safety of the use of β-AB in the treatment of children with superficial JH (n=56) was assessed. Results. The experimental studies in vitro indicate the absence of a negative effect of timolol on the viability, migration and mobility of endothelial cells, fibroblasts and keratinocytes. The results of the studies indicate safety and high clinical efficacy: recovery was observed in 87.5%, a significant improvement - in 7.1%, and effect of treatment was absent in 5.3%. Side effects in the treatment of children (cases of hypoglycemia and heart conduction disorders) were not detected. Conclusion. The results of the study make it possible to recommend the widespread introduction of active anti-angiogenic therapy with non-selective ß-AB timolol for surface JHs.

In order to evaluate the efficacy of clarithromycin in the therapy of urogenital chlamydiosis, 39 male patients were examined. In 26 of them, chlamydiosis occurred in acute form, in 13 men, a chronic course with duration of up to 2.6 years was diagnosed. Patients were assigned to receive clarithromycin at a dose of 500 mg twice a day for 10 days. 4 weeks after the end of treatment, the control of cure was carried out by PCR; and the eradication of the pathogen was noted in all patients. The results obtained make it possible to recommend clarithromycin as an effective treatment for chronic urogenital chlamydiosis. The immunomodulating properties of clarithromycin, proven in a number of studies, allow to reduce the dose of immunomodulating drugs or exclude them from the treatment regimen, which in turn makes it possible to increase the compliance with therapy by reducing the cost of treatment and the number of drugs used.

Halo phenomenon is described as a rim of depigmentation around a variety of skin lesions with different histogenesis. Most frequently it has been reported in cases of melanocytic nevi with an estimated frequency of 1%. Focal depigmentation of hair (leukotrichia, poliosis) represents the rare clinical presentations of halo phenomenon and can be the only clinical sign of halo nevi. A case-report of halo nevus, located on the scalp and manifested by local leukotrichia, as well as report of halo phenomenon around the nevus sebaceous of Jadassohn are described in the article. A review of the literature on halo phenomenon is given in the article, differential diagnosis of leukotrichia is discussed.

To date, the most common viral infection of the genital tract is the human papillomavirus (HPV); its 13 types possess high oncogenic risk. Despite the fact that HPV-6 and HPV-11 are classified as viruses with low oncogenic risk, they can cause severe damage up premalignant and malignant neoplasms of anogenital localization. Authors presents their own clinical observation of the giant condyloma Buschke-Levenshtein in a 31-year-old man with a burdened history of lymphangitis, lymphedema of the upper and lower limbs and lymphadenopathy, which for several years made it difficult to conduct destructive surgical treatment. The patient underwent extensive surgery with total excision of giant condyloma followed by administration of imiquimod 5% cream after complete postoperative recovery of the skin.