Urolenital chlamidiosis in men: approaches to therapy
- Authors: Melnichenko O.O1, Babayev O.R1, Shakhzadov V.V1, Korsunskaya I.M2
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Affiliations:
- MSPCCD of Moscow Healthcare Department
- CCP PCP RAS
- Issue: No 1S (2018)
- Pages: 44-46
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/296515
- ID: 296515
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Open Access
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Abstract
In order to evaluate the efficacy of clarithromycin in the therapy of urogenital chlamydiosis, 39 male patients were examined. In 26 of them, chlamydiosis occurred in acute form, in 13 men, a chronic course with duration of up to 2.6 years was diagnosed. Patients were assigned to receive clarithromycin at a dose of 500 mg twice a day for 10 days. 4 weeks after the end of treatment, the control of cure was carried out by PCR; and the eradication of the pathogen was noted in all patients. The results obtained make it possible to recommend clarithromycin as an effective treatment for chronic urogenital chlamydiosis. The immunomodulating properties of clarithromycin, proven in a number of studies, allow to reduce the dose of immunomodulating drugs or exclude them from the treatment regimen, which in turn makes it possible to increase the compliance with therapy by reducing the cost of treatment and the number of drugs used.
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About the authors
O. O Melnichenko
MSPCCD of Moscow Healthcare Department
O. R Babayev
MSPCCD of Moscow Healthcare Department
V. V Shakhzadov
MSPCCD of Moscow Healthcare Department
I. M Korsunskaya
CCP PCP RAS
Email: marykor@bk.iu
MD, Prof., Head of the Laboratory
References
- Blake D.R., Quinn T.C., Gaydos C.A. Should asymptomatic men be included in chlamydia screening programs? Cost-effectiveness of chlamydia screening among male and female entrants to a national job training program. Sex Transm. Dis. 2008;35:91-101.
- Fine D., Thomas K.K., Nakatsukasa-Ono W., Marrazzo J. Chlamydia positivity in women screened in family planning clinics: Racial/ethnic differences and trends in the northwest U.S., 1997-2006. Public Health Rep. 2012;127:38-51.
- Gewirtzman A., Bobrick L., Conner K., Tyring S.K. Epidemiology of sexually transmitted infections. in: G. Gross, S.K. Tyring (Eds.) Sexually transmitted infections and sexually transmitted Diseases. Berlin, 2011:13-34.
- Schillinger J.A., Dunne E.F., Chapin J.B., et al. Prevalence of Chlamydia trachomatis infection among men screened in 4 U.S. cities. Sex Transm. Dis. 2005;32:74-77.
- Урогенитальный хламидиоз. Учебное пособие/ Под ред. А.В. Молочкова. М., 2014. 40с.
- Батыршина С.В. Урогенитальный хламидиоз: проблемыы, возможности и перспективы диагностики, терапии и профилактики. Лекции для врачей общей практики. Практическая медицина. 2010;02(10).
- World Health Organization. A strategic approach to strengthening control of reproductive tract and sexually transmitted infections: use of the programme guidance tool. WHO Department of Reproductive Health and Research. World Health Organization, 2009. 44 p.
- Мавров Г.И. Контроль инфекций, передающихся половым путем, в Украине. Доктор. 2005;1(27):10-14.
- Нагорный А.Е. Эпидемиология генитального герпеса, хламидиоза и трихомоноза в Украине и регионах в период 2005-2010 годы. Дерматологія та венерологія. 2011; 2(52):5-14.
- Morrison R.P New insights into a persistent problem - chlamydial infections. J. Clin. Invest. 2003;111:1647-49.
- Захарова З.А. Динамика заболеваемости и социальная характеристика больных венерическими болезнями. Российский журнал кожных и венерических болезней. 2004;6:63-5.
- Marks L., Hunter D.J., Alderslade R. Strengthening Public Health Capacities and Services in Europe: a Framework for Action. WHO Regional Office for Europe. World Health Organ ization, 2011. 60 p
- Королев С.В., Козлов С.Н., Андреева И.В. и др. Подходы к диагностике и лечению острого уретрита у мужчин: результаты многоцентрового наблюдательного исследования. Клиническая микробиология и антимикробная химиотерапия. 2011;13(1):4-24.
- Клинические рекомендации по ведению больных с инфекциями, передаваемыми половым путем, и урогенитальными инфекциями. Российское общество дерматовенерологов и косметологов. М, 2012. 112 с.
- Workowski K.A., Bolan G.A. Centers for Disease Control and Prevention (CDC). Sexually Transmitted Diseases Treatment Guidelines, 2015. MMWR Recomm. Rep. 2015;64(RR-03):1-137.
- Королев С.В. Оптимизация антибактериальной терапии острого негонококкового уретрита у мужчин. Дисс. канд. мед. наук. Смоленск, 2012.
- Wang S.A., Papp J.R., Stamm W.E., Peeling R.W, Martin D.H., Holmes K.K. Evaluation of antimicrobial resistance and treatment failures for Chlamydia trachomatis: a meeting report. J. Infect. Dis. 2005;191:917-23.
- Somani J., Bhullar V.B., Workowski K.A., Farshy C.E., Black C.M. Multiple drug resistant Chlamydia trachomatis associated with clinical treatment failure. J. Infect. Dis. 2000;181:1421-27.
- Сурков А.Н. Современные технологии в лечении и профилактике антибиотик-ассоциированной диареи у детей. Вопросы современной педиатрии. 2011;10(5):46-151.
- Кларитромицин. Справочник лекарств РЛС: инструкция, применение и описание вещества Кларитромицин [электронный ресурс] URL: https://www.rlsnet.ru/mnnjndex_id_1759.htm дата обращения: 27.08.2017
- Konstantinidis T., Kambas K., Mitsios A., et al. Immunomodulatory Role of Clarithromycin in Acinetobacter baumannii Infection via Formation of Neutrophil Extracellular Traps. Antimicrob. Agents.Chemother. 2016;60(2):1040-48.
- Потекаев Н.С., Потекаев Н.Н. Кларитромицин в терапии урогенитального хламидиоза Кремлевская медицина. Клинический вестник, № 1. Январ-март 1998 г.
- Mikamo H., Ninomiya M., Tamaya T. Clinical efficacy of clarithromycin against uterine cervical and pharyngeal Chlamydia trachomatis and the sensitivity of polymerase chain reaction to detect C. trachomatis at various time points after treatment. J. Infect. Chemother. 2003;9:282-83.
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