SEROLOGICAL METHODS FOR THE DIAGNOSTICS OF CHLAMIDIAL PROSTATITIS

Background. The diagnosis of chronic urogenital chlamydiosis (UGC) is complex due to its asymptomatic course, as well as the high frequency of false-negative results of molecular-biological tests, including in consequence of inaccessible localization of the pathogen in ascending infection. For this reason, after receiving negative results the doctor should not regard them as an absolute indicator of the absence of chlamydial infection and consider the potentials of indirect serological tests. Objective. Evaluation of the use of a serological test complex for the detection of antichlamydial antibodies in patients with chronic prostatitis. Methods. During the period from 2015 to 2018, 39 patients with chronic prostatitis were examined in the Shchelkovo Dermatovenerologic Dispensary (Moscow region). For the purpose of diagnosis, clinical instrumental molecular-biological and serological tests were conducted. Results. Of the 39 patients examined, chlamydial infection was not detected by PCR and ELISA in 13 (33.3%), in 26 (66.7%) patients it was detected by PCR or serologically, of which in 6 (23.1%) patients C. trachomatis was detected by the PCR method, in 20 (76.9%) - by serological method. Conclusion. The data obtained allow to conclude that it is necessary to supplement the standard diagnostic methods by determining secretory IgA to C. trachomatis of seminal plasma and serum IgG antibodies to the HSP-60, as elevated levels of the latter indicate a persistent chlamydial infection.

chronic prostatitis, diagnosis, molecular-biological analysis, serologic examination, secretory IgA