COMPARATIVE EVALUATION OF THE PROLIFERATIVE ACTIVITY OF CELLS OF KERATOACANTHOMA AND SQUAMOUS CELL SKIN CANCER
- Authors: Kuntsevich Z.S1, Gurevich L.E1
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Affiliations:
- Moscow Regional Scientific Research Clinical Institute n.a. M.F. Vladimirsky
- Issue: No 4S (2018)
- Pages: 53-57
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/296560
- DOI: https://doi.org/10.18565/pharmateca.2018.s5.53-57
- ID: 296560
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Abstract
Background. The histological differentiation of keratoacanthoma (KA) and squamous cell skin cancer (SCSC) is complex, and the mechanisms of their various biological potential are not well understood. Objective: выявить различия пролиферативной активности клеток кератоакантомы и плоскоклеточного рака кожи на основе сравнительного анализа экспрессии пролиферативноклеточного маркера Ki-67 в кератоакантоме и плоскоклеточном раке кожи. Methods. 44 patients with atypical KA, as well as 20 patients with infiltrative-ulcerative SCSC T1N0M0 were examined. Morphological analysis included histological and immunohistochemical (IHC) examination. Results. A comparative semi-quantitative analysis of a number of histological and cytological signs in 44 cases of atypical KA and 20 cases of SCSC showed that they were poorly informative for carrying out a differential diagnosis. However, these two types of tumors significantly differed in the distribution of the Ki67-labeled nuclei of tumor cells: in the case of KA, it was basal, in the case of SCSC - diffuse and irregular. Conclusion. The features of the distribution of nuclei expressing Ki-67 in KA and SCSC are of great diagnostic value for carrying out a differential diagnosis between these two types of skin tumors.
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About the authors
Zh. S Kuntsevich
Moscow Regional Scientific Research Clinical Institute n.a. M.F. Vladimirsky
Email: j_s_k@mail.ru
L. E Gurevich
Moscow Regional Scientific Research Clinical Institute n.a. M.F. Vladimirsky
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