COMPARATIVE EVALUATION OF THE PROLIFERATIVE ACTIVITY OF CELLS OF KERATOACANTHOMA AND SQUAMOUS CELL SKIN CANCER

Background. The histological differentiation of keratoacanthoma (KA) and squamous cell skin cancer (SCSC) is complex, and the mechanisms of their various biological potential are not well understood. Objective: выявить различия пролиферативной активности клеток кератоакантомы и плоскоклеточного рака кожи на основе сравнительного анализа экспрессии пролиферативноклеточного маркера Ki-67 в кератоакантоме и плоскоклеточном раке кожи. Methods. 44 patients with atypical KA, as well as 20 patients with infiltrative-ulcerative SCSC T1N0M0 were examined. Morphological analysis included histological and immunohistochemical (IHC) examination. Results. A comparative semi-quantitative analysis of a number of histological and cytological signs in 44 cases of atypical KA and 20 cases of SCSC showed that they were poorly informative for carrying out a differential diagnosis. However, these two types of tumors significantly differed in the distribution of the Ki67-labeled nuclei of tumor cells: in the case of KA, it was basal, in the case of SCSC - diffuse and irregular. Conclusion. The features of the distribution of nuclei expressing Ki-67 in KA and SCSC are of great diagnostic value for carrying out a differential diagnosis between these two types of skin tumors.

keratoacanthoma, squamous cell skin cancer, differential diagnosis, Ki-67 expression