TOPICAL GLUCOCORTICOID THERAPY OF PSORIASIS AND ATOPIC DERMATITIS


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Abstract

Topical therapy with glucocorticosteroids (GCSs) plays an important role in the treatment of steroid-sensitive dermatoses, including psoriasis and atopic dermatitis, due to the anti-inflammatory, antiproliferative, vasoconstrictive and hyposensitizing effects of these drugs. Dermovate - 0.05% clobetasol propionate is a very strong corticosteroid, allowing to quickly achieve full clinical effect against the background of a low concentration of the active substance, which reduces the risk of systemic side effects and has a favorable safety profile when used correctly. The rational use of topical GCSs in psoriasis and atopic dermatitis is discussed in detail.

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About the authors

V. A Molochkov

Moscow Regional Scientific Research Clinical Institute

Department of Dermatovenereology and Dermatooncology

O. V Matveeva

GSK

MD, Prof., Head of the Department of Dermatovenereology and Dermatooncology

References

  1. Бутов Ю.С., Потекаев Н.Н. Дерматовенерология. Руководство для врачей. М., 2017. 640 с.
  2. Клинические рекомендации по лечению атопического дерматита. РОДВК, 2015. URL: http:// www.cnikvi.ru/docs/ciinic_recs/boiezni-kozhi-i-pridatkov.
  3. Клинические рекомендации по ведению больных атопическим дерматитом / Под ред. А.А. Кубановой. М., 2010. 40 с.
  4. Атопический дерматит. Руководство для врачей. Под ред. Ю.В. Сергеева. М., 2002. 182 с.
  5. Альбанова В.И., Пампура А.Н. Атопический дерматит. Учебное пособие. М., 2014. 128 с.
  6. Lohman M.E., Lie P.A. Comparison of psoriasis and atopic dermatitis guideiines - on argument for aggressive atopic dermatitis management. Pediatr. Dermatoi. 2017;00:1-4 https://doi. org/10.1111/pde.13282.
  7. Eichenfieid L.F., Tom W.L., Chamiin S.L., et ai. Guideiines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J. Am. Acad. Dermatoi. 2014;70:338-51.
  8. Brodell R.T., Bruce S., Hudson C.P., et al. A multicenter, open-label study to evaluate the safety and efficacy of a sequential treatment regimen of clobetasol propionate 0.05% spray followed by calcitriol 3 mg/g ointment in the management of plaque psoriasis. J. Drugs. Dermatol. 2011;10:158-64.
  9. Bhutani T., Zitelli KB, Koo J. Yin-yang strategy: proposing a new, effective, repeatable, sequential therapy for psoriasis. J. Drugs Dermatol. 2011;10:831-34.
  10. Wollenberg A., et al. Proactive treatment of atopic dermatitis in adults with 0,1% tacrolimus ointment. Allergy. 2008;63:742-50.
  11. Fukuie T., Nomura I., Horimukai K., et al. Proactive treatment appears to decrease serum immunoglobulin-E levels in patients with severe atopic dermatitis. Br. J. Dermatol. 2010;163:1127-29. doi: 10.1111/j.1365-2133.2010.09904.x.
  12. Tang T.S., Bieber T., Williams H.C. Are the concepts of induction of remission and treatment of subclinical inflammation in atopic dermatitis clinically useful? J. Allergy Clin. Immunol. 2014;133(6):1615-25.
  13. Bieber T. Atopic dermatitis. Ann. Dermatol. 2010;22:125-37.
  14. Matsumoto K., Saito H. Eczematous sensitization, a novel pathway for allergic sensitization, can occur in an early stage of eczema. J. Allergy Clin. Immunol. 2014;134:865-66.
  15. Celakovska J., Ettlerova K., Ettleret K., al. Sensitization to aeroallergens in atopic dermatitis patients: association with concomitant allergic diseases. J. Eur. Acad. Dermatoi. Venereoi. 2015; 29:1500-505.
  16. Kakinuma T., Nakamura K., Wakugawa M., et ai. Thymus and activation-reguiated chemokine in atopic dermatitis: serum thymus and activation-reguiated chemokine ievei is cioseiy reiated with disease activity J. Aiiergy Ciin. Immunoi. 2001;107:535-41.
  17. Fujisawa T., Nagao M., Hiraguchi Y., et al. Serum measurement of thymus and activation-reguiated chemokine/CCL17 in chiidren with atopic dermatitis: eievated normai ieveis in infancy and age-specific anaiysis in atopic dermatitis. Pediatr. Aiiergy. Immunoi. 2009;20:633-41. doi: 10.1111/j.1399-3038. 2009.00851.x.
  18. Fukuie T., et al. Potential preventive effects of proactive therapy on sensitization in moderate to severe childhood atopic dermatitis: A randomized, investigator-blinded, controliedstudy J. Dermatol. 2016;14:35-42.
  19. Инструкция по медицинскому применению препарата Дермовейт. URL: http://gris. rosminzdrav.ru. [Instructions for medical use of the drug Dermoveit. URL: http://gris.rosminzdrav. ru. (In Russ.)].
  20. Das A., Panda S. Use of Topicai Corti-costeroids in Dermatology: An Evidence-based Approach. Indian J Dermatoi. 2017;62(3):237-50.
  21. Weaver J. Department of Health and Human Services. Memorandum 2001.
  22. Goh C.L., Lim J.T., Leow Y.H., et al., The therapeutic efficacy of mometasone furoate cream 0.1% applied once daily vs ciobetasoi propionate cream 0.05% applied twice daily in chronic eczema. Singapore Med. J. 1999;40(5):341-44.
  23. Ring J., Aiomar A., Bieber T., et al. Guidelines for treatment of atopic eczema (atopic dermatitis) part i. J Eur Acad Dermatoi Venereoi. (JEADV). 2012;26(8):1045-60.
  24. Beattie P.E., et al. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol 2006;155:145-51.
  25. Barnes P.J. Anti-infiammatory actions of glucocorticoids: Molecular mechanisms. Clinical Science 1998;94(6):557-72.
  26. Jacobson C., Cornell R.C., Savin R.C. A comparison of clobetasol propionate 0.05 percent ointment and an optimized betamethasone dipropionate 0.05 percent ointment in the treatment of psoriasis. Cutis. 1986;37(3):213-14, 216, 218-20.
  27. Oakley A. DermNet New Zealand. Topical formulations. Updated February 2016. URL: https://www.dermnetnz.org/topics/topical-formulations/
  28. Keri J.E., et al. Merck Manuals. Principles of Topical Dermatological Therapy. URL: https:// www.msdmanuals.com/en-gb/professional/ dermatologic-disorders/principles-of-topicaldermatologic-therapy/principles-of-topicaldermatologic-therapy.
  29. NICE. Psoriasis. Clinical Knowledge Summaries 2014. http://cks.nice.org.uk/psoriasis.
  30. Bewley A., et al. Expert consensus: time for a change in the way we advise our patients to use topical corticosteroids. Br J Dermatol. 2008;158:917-20.
  31. Long C.C., et al. A practical guide to topical therapy in children. Br J Dermatol. 1998;138:293-96.

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