Current data on the prevalence, risk factors and clinical aspects of Opisthorchis felineus invasion in children in an endemic region
- Authors: Sokolova T.S1, Golovach E.A1, Petrov V.A1, Fedorova O.S.1
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Affiliations:
- Siberian State Medical University
- Issue: Vol 26, No 1 (2019)
- Pages: 56-60
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/296645
- DOI: https://doi.org/10.18565/pharmateca.2019.1.56-60
- ID: 296645
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Abstract
Background. The urgency of the problem of Opisthorchis felineus invasion in pediatrics is attributable to its high incidence in endemic regions and the impact on the health of children, including on the frequency and progression of chronic diseases. Objective: to evaluate the prevalence, intensity, risk factors for O. felineus invasion, as well as the clinical manifestations of the disease in children within the framework of an epidemiological study in an endemic region. Methods. The first stage was planned as a cross-sectional study in a randomized sample; 76 children aged 7-18 years were included. The second stage was conducted as the case-control study, within framework of which two groups were formed: children suffering from O. felineus invasion (n=50, average age 11±3.4 years), and a control group of children without O felineus invasion according to the results of a parasitological examination, as well as without acute and chronic diseases (n=50, 10.3±2.8 years). The study procedures included interviewing a questionnaire containing sections on demographic, socio-cultural, medical data; physical examination, double microscopy of stool samples using Parasep concentrators (Diasys Ltd), biochemical blood test, ultrasound (US) of the hepatobiliary system. Results. The prevalence of O. felineus invasion in children living in the endemic region of Western Siberia (Tomsk Region) is 18.4% and tends to increase with age. In children and adolescents, low intensity invasions prevail. The pediatric population of endemic regions does not have enough knowledge about the methods of infection and prevention of O. felineus invasion. In most cases, a clinically significant form of the disease occurs, affecting the hepatobiliary system and associated with the development of comorbidities. Conclusion. The results of the study dictate the need to develop programs to preserve the health of children in O. felineus endemic regions.
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About the authors
T. S Sokolova
Siberian State Medical University
E. A Golovach
Siberian State Medical University
V. A Petrov
Siberian State Medical University
Olga S. Fedorova
Siberian State Medical University
Email: olga.sergeevna.fedorova@gmail.com
MD, Professor at the Department of Faculty Pediatrics with a Course of Childhood Diseases of the Medical Faculty
References
- Здравоохранение в России. 2017: Статистический сборник. Росстат М., 2017. 170 с. URL: http://www.gks.ru/free_doc/ doc_2017/zdrav17.pdf.
- Баранов А.А., Щербаков П.Л. Детская гастроэнтерология: проблемы и задачи на современном этапе. Вопросы современной педиатрии. 2007;6(5):5-14.
- Бычков В.Г., Крылов Г.Г., Плотников А.О. Описторхоз в Обь-Иртышском бассейне (вопросы этиологии и патогенеза). Медицинская паразитология и паразитарные болезни. 2007;4:3-5
- Огородова Л.М., Деев И.А., Федорова О.С. и др. Распространенность гельминтной инвазии Opisthorchis felineus у детей в Томске и Томской области. Вопросы современной педиатрии. 2011;10(3):43-7.
- Клинические рекомендации (протокол лечения) оказания медицинской помощи детям больным описторхозом. ФГБУ НИИДИ ФМБА России. Угвержден на заседании Профильной комиссии 18 февраля 2014 г. URL: http://niidi.ru/dotAsset/ebd00542-c9ea-438b-9dd9-389358028752.pdf.
- Бражникова Н.А., Цхай В.Ф., Мерзликин Н.В. и др. Описторхозный панкреатит. Анналы хирургической гепатологии. 2012;17( 2):72-9.
- Бражникова Н.А., Цхай В.Ф. Гнойный описторхозный холангит. Анналы хирургической гепатологии. 2009;14(4):28-33.
- Бражникова Н.А., Цхай В.Ф. Клиника, диагностика и лечение осложнений описторхоза. Анналы хирургической гепатологии. 2004;9(2):40-4.
- Sripa B., Tangkawattana S., Brindley P.J. Update on Pathogenesis of Opisthorchiasis and Cholangiocarcinoma. Advances Parasitol. 2018;102:97-113. Doi: 10.1016/ bs.apar.2018.10.001.
- Федорова О.С., Ковширина Ю.В., Ковширина А.Е. и др. Анализ заболеваемости инвазией Opisthorchis felineus и злокачественными новообразованиями гепатобилиарной системы в Российской Федерации. Бюллетень сибирской медицины. 2016;15(5):147-58.
- Fedorova O.S., Fedotova M.M., Sokolova T.S., et ai. Opisthorchis feiineus infection prevaience in Western Siberia: A review of Russian literature. Acta Tropica. 2018;178:196-204. Doi: 10.1016/j. actatropica.2017.11.018.
- Grundy-Warr C., Andrews R.H., Sithithaworn P., et al. Raw attitudes, wetland cultures, life-cycles: socio-cultural dynamics relating to Opisthorchis viverrini in the Mekong Basin. Parasitol Internat. 2012;61(1):65-70. Doi: 10.1016/j. parint.2011.06.015.
- Sripa B., Tangkawattana S., Sangnikul T. The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. Parasitol Internat. 2017;66(4):346-54. Doi: 10.1016/j. parint.2016.11.013.
- О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2017 году: Государственный доклад. М., 2018. 268 с.
- Pozio E., Armignacco O., Ferri F., Gomez M.A. Opisthorchis felineus, an emerging infection in Italy and its implication for the European Union. Acta Tropica. 2013;126(1):54-62. Doi: 10.1016/j. actatropica.2013.01.005.
- Засорина Н.В. Роль медико-социальных критери ев при хроническом описторхозе. Оптимизация диагностики с помощью нейроинформационных технологий. Дисс. канд. мед. наук. 2009.
- Беляева М. И. Эколого-паразитологические и социальные особенности очагов описторхоза в южных районах Тюменской области. Дисс. канд. биол. наук. 2015.
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