Disaccharidase deficiency under the guise of functional bowel disease


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Resumo

Background. Disaccharidase deficiency and functional bowel disorders (FBDs) are largely similar in clinical manifestations and require differential diagnosis due to different pathogenetic approaches to treatment. Objective. To assess the activity of disaccharidases of the mucous membrane of the small intestine in patients with clinical symptoms of FBDs. Methods. 102 patients aged from 18 to 50 years (41 men and 61 women) with clinical symptoms of irritable bowel syndrome (IBS) with a predominance of diarrhea (35 patients), IBS with a predominance of constipation (16), mixed type IBS of (14), functional diarrhea (33) and functional constipation (4) were examined. Disaccharidase activity was evaluated using Dalquist method modified by Trinder in duodenal biopsy specimens obtained during esophagogastroduodenoscopy. Results. Normal enzyme activity was detected in 11 (10.8%) patients. The activity of all the enzymes studied was reduced in 33 (32.3%) patients. In 58 (56.9%) patients, selective reduction in carbohydrase level was found. The basis for the treatment of patients with disaccharidase deficiency was a low-carb diet, intestinal antiseptics and enteroprotectors, which reduced clinical symptoms and increased the activity of membrane enzymes. Conclusion. In 89.2% of patients, the symptoms characteristic of FBDs were associated with a decrease in the activity of membrane enzymes of the small intestine. The reason for the enzymatic deficiency can include prior acute intestinal infections, the use of nonsteroidal anti-inflammatory drugs or other agents that damage the mucous membrane of the small intestine. Treatment with low-carb diet, intestinal antiseptics and enteroprotectors helps to stop pain, abdominal discomfort, flatulence and stool disorders.

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Sobre autores

Asfold Parfenov

A.S. Loginov Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

Email: asfold@mail.ru
MD, Professor, Head of the Department of Intestinal Pathology

O. Akhmadullina

A.S. Loginov Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

E. Sabelnikova

A.S. Loginov Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

L. Krums

A.S. Loginov Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

S. Bykova

A.S. Loginov Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

S. Dbar

A.S. Loginov Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

N. Belostotsky

A.S. Loginov Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

S. Khomeriki

A.S. Loginov Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

E. Bystrovskaya

A.S. Loginov Moscow Clinical Research and Practical Center of the Moscow Healthcare Department

Bibliografia

  1. Drossman D.A., Hasler W.L. Rome IV - Functional GI Disorders: Disorders of Gut-Brain Interaction. Gastroenterology. 2016; 150:1257-1261. Doi: https: //dx. doi. org/10.1053/j. gastro. 2016.03.035.
  2. Lacy B.E., Mearin F., Chang L., et al. Bowel disorders. Gastroenterology. 2016;150:1393-407. Doi: https: // dx.doi.org/10.1053/j.gastro.2016.02.031
  3. Парфенов А.И. Энтерология: руководство для врачей, 2-е изд. М.: МИА, 2009.
  4. Dahlqvist A. Specificity of the human intestinal disaccharidases and implications for hereditary disaccharide intolerance. J. Clin Invest. 1962;41:3-8.
  5. Trinder P. Depermination of glucosa in blood using glucosa oxidase with an alternative oxigen reception. J. Ann. Clin. Biochem.1969;6:24-27.
  6. Farup P.G., Monsbakken K.W., Vandvik P.O. Lactose malabsorption in a population with irritable bowel syndrome: prevalence and symptoms. A case-control study. Scan J. Gastroenterol. 2004;39(7):645-49. Doi: https: //dx.doi.org/10.1080/00365520410005405
  7. Фадеева Н.А., Ручкина И.Н., Парфенов А.И., Щербаков П.Л. Избыточный рост микрофлоры тонкой кишки как причина лактазной недостаточности. Терапевтический архив. 2015;87(2):20-23. doi: 10.17116/terarkh20158720-23.
  8. Nichols B.L. Jr, Adams B., Roach C.M., et al. Frequency of sucrase deficiency in mucosal biopsies. J Pediatr Gastroenterol Nutrit. 2012;55(Suppl 2):S28-30. Doi: https: //dx.doi.org/10.1097/01. mpg.0000421405.42386.64.
  9. Gericke B., Amiri M., Naim H.Y The multiple roles of sucrase-isomaltase in the intestinal physiology. Molecular and Cellular Pediatrics. 2016;;3(1):2. doi: 10.1186/s40348-016-0033-y.
  10. Parker T.J., Woolner J.T., Prevost A.T., et al. Irritable bowel syndrome: is the search for lactose intolerance justified? Eur J Gastroenterol Hepatol. 2001;13(3):219-25. Doi: https: //dx.doi.org/10.1097/00042737-200103000-00001
  11. Fritz E., Hammer J., Vogelsang H. Fructose-free diet does not improve GI symptoms in fructose-intolerant patients if irritable bowel syndrome is present. Gastroenterology. 2003;124(4):A434. Doi: https://dx.doi.org/10.1016/ s0016-5085(03)82194-7.
  12. Shepherd S.J., Lomer M.C., Gibson PR. Short-chain carbohydrates and functional gastrointestinal disorders. Am J Gastroenterol. 2013;108:707-17. Doi: https: // dx.doi.org/10.1038/ajg.2013.96
  13. Staudacher H.M., Whelan K., Irving P.M., et al. Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietary advice in patients with irritable bowel syndrome. J Human Nutr Dietetics. 2011;24:487-95. Doi: https://dx.doi.org/10.1111/ j.1365-277x.2011.01162.x
  14. Mizukami K., Murakami K., Abe T., et al. Aspirin-induced small bowel injuries and the preventive effect of rebamipide. World J Gastroenterol. 2011;17(46):5117-22. doi: 10.3748/wjg.v17.i46.5117.
  15. Zhang S., Qing Q., Bai Y. Rebamipide helpsd efend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: A systematic review and metaanalysis. Dig. Dis. Sci. 2013;7:1991-2000. doi: 10.1007/s10620-013-2606-0.

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