Cerebral microangiopathy associated with age and/or arterial hypertension: clinical and pathogenetic aspects, approaches to therapy


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详细

Cerebral microangiopathy (CMA) associated with age and/or arterial hypertension is considered the most common sporadic form of damage to the small vessels of the brain. The clinical symptoms of CMA, including progressive cognitive deficit, gait disturbance, sphincter dysfunction and mental disorders, severely disrupt the social adaptation of an elderly person. The article discusses the correlates of clinical symptoms and MRI signs of CMA, as well as clinical approaches to the early diagnosis and treatment of CMA. Early diagnosis and treatment of cognitive deficiency is the best prevention of vascular dementia, which can have a tremendous impact on public health.

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作者简介

O. Vorob'eva

Sechenov First Moscow State Medical University (Sechenov University)

Email: oyvorobeva@mail.ru
MD, Professor

参考

  1. Wardlaw J.M., Smith E.E., Biessels G.J., et al. STandards for Reporting Vascular changes on nEuroimaging (STRIVE v1).Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet. Neurol. 2013;12:822-38. Doi: 10.1016/ S1474-4422(13)70124-8.
  2. Poggesi A, Pantoni L., Inzitari D. Consequences of cerebral small vessel disease: disability, mortality, and prognosis. In: Pantoni L and Gorelick PB (eds) Cerebral small vessel disease. Cambridge University Press: Cambridge, UK. 2014. P. 273-382.
  3. Benarroch E. Neurovascular unit dysfunction. Neurol. 2007;68;1730-32.
  4. Kearney-Schwartz A., Rossignol P., Bracard S., et al. Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke. J Cerebral Circulation. 2009;40:1229-36. Doi: 10.1161/ STROKEAHA.108.532853.
  5. Ohmine T., Miwa Y, Yao H., et al. Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects. Hypertens. Res.: official Journal of the Japanese Society of Hypertension. 2008;31:75-81. doi: 10.1291/hypres.31.75.
  6. Vermeer S.E., Longstreth W.T. Jr., Koudstaal PJ. Silent brain infarcts: a systematic review. Lancet. Neurol. 2007;6(7):611-19.
  7. van der Holst H.M., van Uden I.W, Tuladhar A.M., et al. Factors associated with 8-year mortality in older patients with cerebral small vessel disease: the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) study. JAMA. Neurol. 2016;73:402-9. doi: 10.1001/jamaneurol.2015.4560.
  8. Starr J.M., Leaper S.A., Murray A.D., et al. Brain white matter lesions detected by magnetic resonance [correction of resosnance] imaging are associated with balance and gait speed. J Neurol Neurosurg Psychiatry. 2003; 74:94-8.
  9. Tang W.K., Chen Y.K., Lu J.Y, et al. Microbleeds and post-stroke emotional lability. J Neurol Neurosurg Psychiatry. 2009;80(10):1082-86. doi: 10.1136/jnnp.2009.175372.
  10. Poggesi A, Pracucci G., Chabriat H., et al. Urinary complaints in nondisabled elderly people with age-related white matter changes: the Leukoaraiosis And DISability (LADIS) Study. J Am Geriatr Soc. 2008;56(9):1638-43. doi: 10.1111/j.1532-5415.2008.01832.x.
  11. Shah R. The role of nutrition and diet in Alzheimer disease: а systematic review. J Am Med Dir Assoc. 2013;14:398-402. Doi: 10.1016/j.
  12. Benavente O.R., Coffey C.S., Conwit R., et al. Bloodpressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. Lancet. 2013;382(9891):507-15. Doi: 10.1016/ S0140-6736(13)60852-1
  13. Erdos B., Snipes J.A., Tulbert C.D., et al. Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P) H oxidasedependent superoxide production. Am J Physiol Heart Circ Physiol. 2006;290(3): 1264-70
  14. Pearce L.A., McClure L.A., Anderson D.C., et al. Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial. Lancet. Neurol. 2014;13(12):1177-85. Doi: 10.1016/ S1474-4422(14)70224-8
  15. Tian J., Liu Y, Chen K. Ginkgo biloba Extract in Vascular Protection: Molecular Mechanisms and Clinical Applications. Curr Vasc Pharmacol. 2017;15(6):532-48. doi: 10.2174/157016111 5666170713095545
  16. Yin B., Xu Y, Wei R., Luo B. Ginkgo biloba on focal cerebral ischemia: a systematic review and metaanalysis. Am J Chin Med. 2014;42(4):769-83. doi: 10.1142/S0192415X14500499
  17. Kudolo G.B. The effect of 3-month ingestion of ginkgo biloba extract on pancreatic beta-cell function in response to glucose loading in normal glucose tolerant individuals. J Clin Pharmacol. 2000;40:647-54.
  18. Brinkley T.E., Lovato J.F., Arnold A.M., et al. Effect of ginkgo biloba on blood pressure and incidence of hypertension in elderly men and women. Am J Hypertens. 2010;23:528-33. Doi: 10.1038/ ajh.2010.14.
  19. Keheyan G, Dunn L.A., Hall W.L. Acute effects of ginkgo biloba extract on vascular function and blood pressure. Plant. Foods Hum Nutr. 2011;66:209-11. doi: 10.1007/s11130-011-0234-4.
  20. Gardner C.D., Zehnder J.L., Rigby A.J., et al. Effect of ginkgo biloba (EGB 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: A randomized clinical trial. Blood Coagul Fibrinolys. 2007;18:787-93.
  21. Wolf H.R. Does ginkgo biloba special extract egb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily? Drugs R D. 2006;7:163- 72
  22. Solfrizzi V, Panza F. Plant-based nutraceutical interventions against cognitive impairment and dementia: meta-analytic evidence of efficacy of a standardized Gingko biloba extract. J Alzheimers Dis. 2015;43(2):605-11. doi: 10.3233/JAD-141887

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