Interim assesment of the results of a clinical study of the regularities of changes in the patterns of lipid peroxidation -antioxidant defence in stomach cancer


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Abstract

Background. Stomach cancer (SC) occupies a leading position in the structure of oncological morbidity and mortality. Violation of the regulation of the processes of lipid peroxidation (LP) - antioxidant defence (AOD) causes a decrease in the body’s resistance and contributes to the development and progression of diseases. Objective. Evaluation of the patterns of LP- AOD in SC. Methods. The parameters of the immune system and LP-AOD in chronic atrophic gastritis (CAG) and SC were evaluated for one year after the detection of pathology. The study included 50 patients with CAG and 50 patients with SC. The control group consisted of 85 healthy donors. The study material was venous blood, which was taken from patients upon admission before the start of the pathogenetic treatment. The study was conducted from June to September 2019, venous blood was taken from patients one time. LP-AOD indicators were determined by spectrophotometric methods. For testing statistical hypotheses, the critical level of significance was taken equal to p<0.05. Results. Compared to the control group, patients with SC has increased blood plasma malondialdehyde, catalase, glutathione-S-transferase, glutathione peroxidase, and ceruloplasmin levels, and prooxidant processes prevailed over antioxidant ones. The highest values of indicators were detected at stage III disease. Compared to patients with CAG, patients with SC had more pronounced increase in the malondialdehyde levels. A decrease in the activity of the superoxide dismutase enzyme indicates inhibition of the leading enzyme in the enzymatic link of AOD. An increase in ceruloplasmin protein proves its compensatory activation in oxidative stress. Conclusion. High malondialdehyde and ceruloplasmin levels, low activity of superoxide dismutase are pathogenetic mechanisms in the transformation of CAG into SC.

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About the authors

O. V Smirnova

Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" “Research Institute of Medical Problems of the North"

Email: ovsmirnova71@mail.ru
MD, Head of the Laboratory of Clinical Pathophysiology, Research Institute of Medical Problems of the North 3G, Partizan Zheleznyaka Street, Krasnoyarsk 660022, Russian Federation

V. V Tsukanov

Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" “Research Institute of Medical Problems of the North"

Krasnoyarsk, Russia

A. A Modestov

Krasnoyarsk Regional Clinical Oncology Center n. a. A.I. Kryzhanovsky

Krasnoyarsk, Russia

A. A Sinyakov

Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" “Research Institute of Medical Problems of the North"

Krasnoyarsk, Russia

O. L Moskalenko

Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" “Research Institute of Medical Problems of the North"

Krasnoyarsk, Russia

N. G Elmanova

Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" “Research Institute of Medical Problems of the North"

Krasnoyarsk, Russia

E. S Ovcharenko

Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" “Research Institute of Medical Problems of the North"

Krasnoyarsk, Russia

N. M Titova

Siberian Federal University

Krasnoyarsk, Russia

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